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基于FD-CPOCT的高分辨率关节软骨次表面成像
          
High-resolution subsurface articular cartilage imaging based on Fourier-domain common-path optical coherence tomography

摘    要
利用傅氏域全光程光学相干断层扫描(FD-CPOCT)技术对关节软骨进行次表面成像。与皮下注射器集成的裸光纤探头达到了所需求的刚度,纵向扫描时的微尺度弯曲更小。我们将探针和样本同时沉浸在盐溶液中,发现不仅可以减小发散角,还可以增加信噪比。该系统可以区分鸡的膝关节软骨区的特征,同时分辨不同的微结构损伤,所以可以用于诊断早期的关节炎和外科手术内在显微技术。
标    签 COT,成像系统,相干光学效应,光纤光学   110.4500   170.0110   030.1670   060.2310  
 
Abstract
We demonstrate the subsurface imaging of an articular cartilage using Fourier-domain common-path optical coherence tomography. The bare fiber probe integrated with a hypodermic needle provides the rigidness required to perform lateral scanning with less microscale bending. By submerging both the probe and the specimen into saline solution, we not only reduce the beam divergence, but also increase the signal-to-noise ratio compared with the measurement in free space. Our system can di?erentiate the characteristic cartilage zones and identity various micro-structured defects in an ex vivo chicken knee cartilage, thus demonstrating that it could be used to conduct early arthritis diagnosis and intraoperative endo-microscopy.

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收稿日期 2009/9/17

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备注This work was supported by the second stage of the Brain Korea 21 Project in 2009 and a Korean Science and Engineering Foundation (KOSEF) grant funded by the Korea Government (MEST) (No. R01-2008-000-200890).

引用该论文: Jae-Ho Han,Xuan Liu,Jin U. Kang,Chul Gyu Song. High-resolution subsurface articular cartilage imaging based on Fourier-domain common-path optical coherence tomography[J]. 中国光学快报, 2010, 8(2): 167~169


被引情况:


【1】Jae-Ho Han,J. U. Kang, "用于光频域断层成像的集成微透镜光纤导管探针",Chinese Optics Letters 9, 90608-90610(2011)

【2】孟卓,姚晓天,姚晖,刘铁根,万木森,连小丽, "基于光学相干层析图像的离体牙三维重建",光学学报 30, 100412--1(2010)

【3】谭默言,李浩川,黄秋实,周洪军,霍同林,王晓强,朱京涛, "12.5-28.5 nm波段Mo/Si非周期多层膜宽带反射镜",Chinese Optics Letters 9, 23102-23105(2011)

【4】陈海宇,翁国星,李志芳,李晖,蔡吓妹, "基于光学相干层析成像技术判定心肌缺血再灌注损伤程度",Chinese Optics Letters 9, 21701-21703(2011)

【5】, "Thinning and polishing of cross-section of depth-graded WSi2/Si multilayer for linear zone plate application",Chinese Optics Letters 10, 13103-13106(2012)



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