肿瘤靶向治疗的研究是当今生物医学界的研究热点。寻找具有肿瘤靶向性的高效体内运输载体是实现肿瘤靶向治疗的关键。采用整合素αvβ3单克隆抗体作为肿瘤靶向分子, 以单壁碳纳米管(SWNT)作为运输载体, 通过碳纳米管表面的适当功能化, 将整合素αvβ3单抗标记在碳纳米管上, 构建整合素αvβ3单抗标记的碳纳米管新型肿瘤靶向探针; 研究探针在人脐静脉内皮细胞HUVEC和整合素αvβ3高表达的人脑神经胶质瘤细胞U87MG的肿瘤靶向性。实验结果表明, 这种整合素αvβ3单抗标记的碳纳米管探针对U87MG细胞靶向选择性高, 将能成为一种有潜力的药物输送及肿瘤分子影像的新型肿瘤靶向载体。

The pursuit of efficient and highly target-selective transporters is an active topic in cancer targeting therapy. A novel cancer-targeting probe based on integrin αvβ3 monoclonal antibody labeled carbon nanotubes was developed to investigate cancer cell targeting in vitro. The results revealed that the system had a high efficiency in cancer cell targeting in integrin αvβ3 positive U87MG cells but low targeting in HUVEC cells, indicating that the high efficiency was due to the specific targeting property of integrin αvβ3 monoclonal antibody. Thus, the integrin αvβ3 monoclonal antibody labeled single-walled carbon nanotube (SWNT) probe is a potential carrier-candidate for cancer-imaging and drug-delivering in cancer therapy.