报道了一种在铜片上采用原位生长法制备Cu₂O-Ag表面增强拉曼光谱(SERS)基底的方法。通过优化制备Cu₂O时退火的温度和时间,以及制备Cu₂O-Ag时AgNO₃的浓度和反应时间,制备了Cu₂O-Ag基底,具有良好的拉曼增强效果。基底表面形成的凹形空间和均匀密布的Ag 纳米粒子提供了丰富的SERS“热点”,且该基底具有较好的疏水性、均匀性、稳定性和灵敏度,对探针分子罗丹明6G的检测限为0.78 nM。该基底对多种违禁药物都有很好的灵敏度,拉曼强度与药物浓度具有良好的定量关系,孔雀石绿、恩诺沙星和呋喃西林的检测限分别为4.9 nM、0.72 μM和0.12 μM。本文方法具有工艺简单、成本低、SERS活性高等优点,在环境监测领域具有较好的应用前景。

This paper reports a method of fabricating the Cu₂O-Ag SERS substrate by in-situ growth on a copper sheet. The as-fabricated substrate has considerable Raman enhancement after we optimized the annealing temperature and time for Cu₂O fabrication and the AgNO₃ concentration and reaction time for Cu₂O-Ag fabrication. In addition, the concave spaces on the substrate surface and the uniformly distributed Ag NPs provided rich SERS “hot spots”. The substrate also has good hydrophobicity, homogeneity, stability, and sensitivity, and it can detect R6G with the limit of detection (LOD) of 0.78 nM. Furthermore, the substrate has great sensitivity towards several prohibited drugs, and the Raman intensity has an excellent quantitative relationship with drug concentration. To be specific, the LODs for malachite green, enrofloxacin, and nitrofurazone are 4.9 nM, 0.72 μM, and 0.12 μM, respectively. In conclusion, the proposed method has a simple process, low costs, and high SERS activity, indicating bright application prospects for environmental monitoring.