同型半胱氨酸是一种含硫氨基酸, 为蛋氨酸和半胱氨酸代谢过程中产生的重要中间产物, 它在人体血液或尿液中浓度含量过高时会大幅增加心血管疾病、老年痴呆、骨折等疾病的发病风险。基于太赫兹时域光谱系统, 针对液体状态下同型半胱氨酸的检测提出了浓缩富集再烘干的处理方法, 有效测量了不同浓度下同型半胱氨酸的太赫兹吸收光谱。经过与拉曼光谱方法的结果比对, 证明太赫兹检测的精度比拉曼光谱检测的精度提升了3倍。该结果对临床医学中同型半胱氨酸相关疾病的准确、快速诊断具有重要意义。

Homocysteine is a sulfur-containing amino acid, which is an important intermediate product produced during the metabolism of methionine and cysteine. High concentration of homocysteine in human blood or urine will significantly increase the risk of cardiovascular disease, alzheimer′s disease, bone fracture and other diseases. Based on terahertz time domain spectroscopy (THz-TDS), a method of concentration, enrichment and drying was proposed for the detection of homocysteine in liquid state. The THz absorption spectra of homocysteine at different concentrations were measured effectively. Compared with the results of Raman spectroscopy, the accuracy of terahertz detection was three times higher than that of Raman spectroscopy. The results were of great significance for the accurate and rapid diagnosis of homocysteine-related diseases in clinical medicine.