糖尿病日益严重地威胁人类健康,但无创血糖检测的方法仍未能在临床上应用,为了解决这一重要问题,从源头进行探索,研究光源随葡萄糖质量浓度变化的光谱特性。在600~1300 nm的波长范围内研究不同葡萄糖质量浓度的溶液的吸收光谱特性和不同葡萄糖质量浓度的2% Intralipid组织模拟液的反射光谱特性,利用单调性、线性度和灵敏度对光谱特性进行分析。实验结果表明,吸收光谱在1140~1210 nm和1130~1200 nm的波长范围内的光波和反射光谱在1010~1130 nm和1150~1300 nm的波长范围内的光波,具有单调性、出色的线性度、灵敏度高的特点。因此认为具有这些特征的光波应用于无创血糖的检测,有助于提高准确性和灵敏度,推动光学无创血糖检测的方法进入临床应用。

Diabetes is increasingly threatening human health. However, noninvasive blood glucose detection methods for clinical use have not yet been developed. To solve this crucial problem, we study the spectral characteristics of light source through different mass concentrations of glucose in a solution. The wavelength range is 600-1300 nm, and the absorption spectral characteristics of glucose solutions with different mass concentrations and the reflection spectral characteristics of 2% Intralipid tissue phantoms with different glucose mass concentrations are studied. The spectral characteristics are evaluated based on their monotonicity, linearity and sensitivity. Experimental results show that light waves are absorbed in the range of 1140-1210 and 1130-1200 nm and those reflected in the range of 1010-1130 and 1150-1300 nm exhibited monotonicity, excellent linearity, and high sensitivity. Thus, light waves with these characteristics are expected to realize noninvasive blood glucose detection and also to improve accuracy and sensitivity, thereby promoting the application of optical noninvasive methods in clinical blood glucose detection.