激光与光电子学进展, 2020, 57 (17): 170005, 网络出版: 2020-09-01
光热转换纳米材料在肿瘤光热治疗中的应用 下载: 2912次
Application of Photothermal Conversion Nanomaterials in Tumor Photothermal Therapy
材料 光热效应 光热转换纳米材料 近红外光 光热治疗 肿瘤治疗 materials photothermal effect photothermal conversion nanomaterials near-infrared light photothermal therapy tumor treatment
摘要
癌症治疗一直是现代医学界最大的难题之一。因为放疗和化疗会带来一定的副作用,因此,通过静脉注射光热剂使其在肿瘤组织中积累,进而在近红外光照射下产生足够的热量来消融实体肿瘤的光热治疗法引起了研究人员的广泛关注。该方法由于具有照射光易聚焦和调整的特性而使得局部治疗过程能够以非侵入、直接和精准的方式进行。这篇综述首先归纳了近年来基于光热转换纳米材料的光热剂在消融实体肿瘤研究方面的主要进展,然后总结了提高光热治疗效果的不同策略,最后讨论了基于光热转换纳米材料的肿瘤光热治疗在临床应用方面面临的局限性和挑战。
Abstract
Curing cancer has been one of the greatest conundrums in the modern medical field. Because of side-effects associated with radiotherapy and chemotherapy, photothermal therapy ( PTT) utilizing photothermal therapeutic agents (PTA)—accumulate in tumor tissues by intravenous injection—to further generate sufficient heat under near-infrared (NIR) light irradiation for solid tumor ablation has attracted extensive attention of researchers. The method allows the local treatment process to be performed in a non-invasive direct and accurate manner due to the easy focusing and tunable properties of the incident light. In this review, we first summarize the major advances in PTA based on photothermal conversion nanomaterials in the study of ablation of solid tumors in recent years. Second, we summarize the different strategies to improve therapeutic efficacy. Finally, the limitations and challenges in the clinical application of photothermal tumor therapy based on photothermal conversion nanomaterials are discussed.
李治, 千维娜, 魏思敏, 闫浩, 靳如意, 郭惠. 光热转换纳米材料在肿瘤光热治疗中的应用[J]. 激光与光电子学进展, 2020, 57(17): 170005. Zhi Li, Weina Qian, Simin Wei, Hao Yan, Ruyi Jin, Hui Guo. Application of Photothermal Conversion Nanomaterials in Tumor Photothermal Therapy[J]. Laser & Optoelectronics Progress, 2020, 57(17): 170005.