中国激光, 2018, 45 (3): 0307008, 网络出版: 2018-03-06
光声显微成像技术研究进展及其应用 下载: 2727次特邀综述
Progress and Application of Photoacoustic Microscopy Technique
医用光学 光声成像 光声显微成像 多尺度光声成像 多参量光声成像 多模态光声成像 生物医学 medical optics photoacoustic imaging photoacoustic microscopy multiscale photoacoustic imaging multiparameter photoacoustic imaging multimodality photoacoustic imaging biomedicine
摘要
光声显微成像技术是近年发展迅速的一种基于光学吸收差异的成像技术,它继承了光学成像对比度高、超声成像深度深的优点,表现出纯光学显微成像技术所无法比拟的优越性。光声显微成像实现了从声学分辨率至光学分辨率的多尺度成像,发展出从单纯的吸收结构到功能的多参量成像、从依靠内源吸收体到外源对比剂的多对比度成像、从依赖超声换能器到全光学激发与探测、从单一吸收成像到与光学相干层析成像、荧光成像、双光子成像、二次谐波成像等结合形成多模态的光声显微成像技术。现已在血管生物学、肿瘤学、神经学、眼科学,以及皮肤学等生物医学领域得到应用。
Abstract
Photoacoustic microscopy is a fast-developing imaging technology, which depends on the optical absorption differences and inherits high contrast of optical imaging and deeper depth of ultrasound imaging. Thus, photoacoustic microscopy presents more merit than optical microscopy. Photoacoustic microscopy realizes multiscale imaging from acoustical resolution to the optical resolution, which provides multi-parameters imaging from simple absorption structure to its function, multi-contrast imaging from endogenous contrast agents to exogenous contrast agent, and imaging from ultrasound-transducer-based to all-optical excitation and detection, and multimodality imaging combined with optical coherence tomography, fluorescence imaging, two-photon imaging, second harmonic imaging, etc. Photoacoustic microscopy is widely applied in the field of biomedicine, such as vascular biology, oncology, neurology, ophthalmology, dermatology, and so on.
陈重江, 杨思华, 邢达. 光声显微成像技术研究进展及其应用[J]. 中国激光, 2018, 45(3): 0307008. Chen Zhongjiang, Yang Sihua, Xing Da. Progress and Application of Photoacoustic Microscopy Technique[J]. Chinese Journal of Lasers, 2018, 45(3): 0307008.