高通量药物筛选是创新药物研究的重要内容,本文综合介绍了高通量药物筛选的研究现状及发展趋势,及目前遇到的一些问题,如随着样品的体积达到微升量级时,目前所采用的孔板筛选遇到了一些难以克服的障碍,使化合物和药物靶点的相互作用难以进行等.针对这些问题,本文介绍了一种新的以自编码光谱识别微球为基础的新型高通量药物筛选技术在高通量药物筛选中的应用,同时简要介绍了我们目前所做的一些工作.

High throughput drug screening is an important content of novel drug researches. The works of high throughput drug screening were reviewed in this paper; the bottleneck was also introduced. For example, when the solution is～ μl, some problems are met, and the interaction of chemical with drug target is difficult to detect. Aimed at these, a novel opticalcoded technology based on spectroscopically recognizable barcoded beads is presented for its application in high throughput screening (HTS), and our works on it were also showed.