再狭窄是困扰冠心病介入治疗的主要问题,目前尚无完善的解决方法.低强度激光是可用于血管内照射的一种照射源,以其不发热,非损害的光生物学过程为特征,应用更为安全、有效和简便易行,而且低强度激光已在创伤修复等领域应用多年,证明可以促进伤口愈合或调节细胞生理过程.本文概述了再狭窄发生机制,探讨了低强度激光用于预防再狭窄的可能机理,总结了有关动物试验和初期临床应用的结果,认为低强度激光作为一种血管成形术后再狭窄的防治手段,无疑具有良好的前景.

Percutaneous transluminal coronary angioplasty(PTCA) heralded a new era and launched the field of interventional cardiology.However,the over-compensatory wound healing response to angioplasty causing restenosis significantly limits the long-term success.The problem has not been well solved now.Recently,low-intensity laser causes much attention as a new way to prevent the restenosis.This review outlines the possible mechanisms,summarizes the results of animal studies and early clinic applications,concludes that low-intensity laser as a method to prevent restenosis has promising future.