摘要

为了研究光动力治疗(PDT)中各个因素作用的规律,帮助临床采取有效的治疗方案,针对鲜红斑痣(PWS)组织特性,将光动力治疗中组织光分布、单线态氧产生、光敏剂漂白过程和光敏剂扩散过程结合起来,建立适合于光动力治疗鲜红斑痣病变的系统模型。利用建立的模型,对临床中出现的第二光斑治疗效果差的问题进行仿真研究,发现影响其治疗效果的因素,并通过仿真实验提出改进其治疗效果的新方案。通过临床实验,证明了新方案的有效性和模型的有效性。研究结果说明,针对特定的病例条件建立仿真模型,通过仿真实验可以为临床和理论研究提供一种有效的分析方法。

Abstract

Treatment of port wine stain (PWS) by photodynamic therapy (PDT) has been under development over last years. To study the acting factors on vascular selectivity of photodynamic and help the doctor confirm therapy plan in clinic, the mathematics modeling of photodynamic therapy treating port wine stain is built. The modeling include light distribution in tissue, production of singlet oxygen, diffusion of photosensitizers and photobleaching. Using the model, a problem of therapeutic effect in clinic is analyzed and a new therapy scheme is recommended. The scheme is proved to be effective in the clinic experiment.

补充资料

中图分类号：TP 391.9;R 318.51

所属栏目：生物医学光子学与激光医学

收稿日期：2005-09-07

修改稿日期：2006-01-08

网络出版日期：--

作者单位    点击查看

联系人作者：程刚(chenggang@bit.edu.cn)

备注：程刚(1981—),男,河南焦作人,北京理工大学博士研究生,主要从事光动力治疗鲜红斑痣系统建模研究。

【1】Liu Qingsen, Huang Yingcai, Li Junheng. Progress in research on photodynamic therapy in gastrointestinal tumor [J]. Chin. J. Laser Med. Surg., 1994, 3(2):108～109
刘庆森,黄英才,李峻亨. 光动力治疗消化道肿瘤的进展[J]. 中国激光医学杂志, 1994, 3(2):108～109

【2】Tom G. Sutedja, Pieter E. Postmus. Photodynamic therapy in lung cancer. A review [J]. Journal of Photochemistry and Photobiology B: Biology, 1996, 36:199～204

【3】Luo Ronghui, Chen Xiangcai, Liu Wanhua et al.. Injurious and immune effect of photodynamic therapy on mice bearing louis lung cancer [J]. Chinese J. Lasers, 2002, A29(8):763～765
罗荣辉,陈香才,刘婉华 等. 光动力疗法对Louis肺癌鼠的杀伤及免疫效应[J]. 中国激光, 2002, A29(8):763～765

【4】Gu Ying, Li Junheng, Guo Zhonghe et al.. Port wine stain treated by photodynamic therapy [J]. Beijing Medical Journal, 1991, 13:317
顾瑛,李峻亨,郭中和 等. 光动力疗法治疗鲜红斑痣[J]. 北京医学, 1991, 13:317

【5】Chen Wenhui, Yu Jianxin, Yao Jianzhong et al.. Pharmacokinetic studies on hematoporphyrin monomethyl ether: A new promising drug for photodynamic therapy of tumors [J]. Chin. J. Laser Med. Surg., 2000, 9(2):105～108
陈文晖,余建鑫,姚建忠 等. 光动力治癌药血啉甲醚的药代动力学研究[J]. 中国激光医学杂志, 2000, 9(2):105～108

【6】M. Forrer, T. Glanzmann, D. Braichotte et al.. In VIVO measurement of fluorescence bleaching of meso-tetra hydroxy phenyl chlorin (mTHPC) in the esophagus and the oral cavity [C]. SPIE, 1995, 2627:33～39

【7】Irene Georgakoudi, Michael G. Nichols, Thomas H. Foster. The mechanism of photofrin photobleaching and its consequences for photodynamic dosimetry [J]. Photochemistry and Photobiology, 1997, 65(1):135～144

【8】William P. Thorpe, Mehmet Toner, Robert M. Ezzell et al.. Dynamics of photoinduced cell plasma membrane injury [J]. Biophysical Journal, 1995, 68:2198～2206

【9】Thomas A. Dahl. Direct exposure of mammalian cells to pure exogenous singlet oxygen (1ΔgO2) [J]. Photochemistry and Photobiology, 1993, 57(2):248～254

【10】Zhou Guoyu, Zhang Zhiyuan, Li Jiang. Computed assessment of pathological images on 52 case′ biopsies of port wine stain [J]. Chin. J. Laser Med. Surg., 1999, 9(2):112～115
周国瑜,张志愿,李江. 52例鲜红斑痣颜色类别的病理图像计算机分析[J]. 口腔颌面外科杂志, 1999, 9(2):112～115

【11】Gerald W. Lucassen, Wim Verkruysse, Marleen Keijzer et al.. Light distributions in a port wine stain model containing multiple cylindrical and curved blood vessels [J]. Lasers in Surgery and Medicine, 1996, 18:345～357

【12】Lai Jiancheng, Li Zhenhua, Wang Chunyong et al.. Angular distribution of backscattered light from locally pathological tissues irradiated by pencil light [J]. Acta Optica Sinica, 2003, 23(11):1403～1408
来建成,李振华,王春勇 等. 线光束照射下局部病变组织背散射场角分布研究[J]. 光学学报, 2003, 23(11):1403～1408

【13】Wim Verkruysse, John W. Pickering, Johan F. Beek et al.. Modelling the effect of wavelength on the pulsed dye laser treatment of port wine stains [J]. Appl. Opt., 1993, 32(4):393～398

【14】Cheng Gang, Zhong Qiuhai, Liu Fanguang et al.. Modeling and simulation of the acting factors on vascular selectivity of photodynamic therapy [J]. Chinese J. Lasers, 2005, 32(6):864～868
程刚,钟秋海,刘凡光 等. 鲜红斑痣光动力治疗模型仿真初步研究[J]. 中国激光, 2005, 32(6):864～868

【15】Xu Yunzhang, Chen Shenglin, Chen Yudong et al.. Pharmacokinetic studies on photosensitizer (PSD-007) [J]. Acad. J. Sec. Mil. Med. Univ., 1986, 7(2):82～85
徐允璋,陈绳林,陈宇东 等. 癌光啉静脉滴注后的临床药物动力学研究[J]. 第二军医大学学报, 1986, 7(2):82～85

【16】Wang Kai, Gu Ying, Liu Fanguang et al.. The several clinic questions of port wine stain treated by photodynamic therapy [J]. Chin. J. Laser Med. Surg., 2002, 11(3):190～192
王开,顾瑛,刘凡光 等. 光动力疗法治疗鲜红斑痣在临床应用中应注意的几个问题[J]. 中国激光医学杂志, 2002, 11(3):190～192

【17】Gu Ying, Liu Fanguang, Wang Kai et al.. A clinic analysis of 1216 cases of port wine stain treated by photodynamic therapy [J]. Chin. J. Laser Med. Surg., 2001, 10(2):86～89
顾瑛,刘凡光,王开 等. 光动力疗法治疗鲜红斑痣1216例临床分析[J]. 中国激光医学杂志, 2001, 10(2):86～89

引用该论文

程刚,钟秋海,黄乃艳,顾瑛. Mathematics Modeling and Clinic Experiment of Photodynamic Therapy for Port Wine Stain[J]. Chinese Journal of Lasers, 2006, 33(6): 857-862

程刚,钟秋海,黄乃艳,顾瑛. 鲜红斑痣光动力治疗数学模型及临床验证[J]. 中国激光, 2006, 33(6): 857-862

被引情况

【1】张红雨,马文江,邹朝晖,高卫平,薛志孝,李迎新. 光动力法制备抗小鼠H22肝癌的肿瘤疫苗. 中国激光, 2008, 35(4): 631-634

【2】周致富,辛慧,陈斌,王国祥. 激光手术喷雾冷却中单个液滴蒸发特性. 中国激光, 2008, 35(6): 952-956

【3】陈冠楠,黄祖芳,陈荣,林居强,杨坤涛,李钻芳. DHL细胞中5-ALA代谢PpⅨ的定位分析. 光学学报, 2009, 29(6): 1605-1608

【4】邹朝晖,高平,阴慧娟,李迎新. 光动力疗法对人工龋口腔生物膜菌斑的影响. 中国激光, 2009, 36(10): 2700-2704

【5】陈洪丽,阴慧娟,徐增瑞,王明辉,郑立卿,李迎新. PsD007诱导光动力疗法对人喉癌细胞的杀伤作用. 中国激光, 2013, 40(5): 504003--1

【6】李艳,李葆华. 基于计算机模拟的葡萄酒色斑激光热疗中喷射冷却机理的数值分析. 激光与光电子学进展, 2017, 54(2): 21701--1