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鲜红斑痣光动力治疗数学模型及临床验证

Mathematics Modeling and Clinic Experiment of Photodynamic Therapy for Port Wine Stain

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摘要

为了研究光动力治疗(PDT)中各个因素作用的规律,帮助临床采取有效的治疗方案,针对鲜红斑痣(PWS)组织特性,将光动力治疗中组织光分布、单线态氧产生、光敏剂漂白过程和光敏剂扩散过程结合起来,建立适合于光动力治疗鲜红斑痣病变的系统模型。利用建立的模型,对临床中出现的第二光斑治疗效果差的问题进行仿真研究,发现影响其治疗效果的因素,并通过仿真实验提出改进其治疗效果的新方案。通过临床实验,证明了新方案的有效性和模型的有效性。研究结果说明,针对特定的病例条件建立仿真模型,通过仿真实验可以为临床和理论研究提供一种有效的分析方法。

Abstract

Treatment of port wine stain (PWS) by photodynamic therapy (PDT) has been under development over last years. To study the acting factors on vascular selectivity of photodynamic and help the doctor confirm therapy plan in clinic, the mathematics modeling of photodynamic therapy treating port wine stain is built. The modeling include light distribution in tissue, production of singlet oxygen, diffusion of photosensitizers and photobleaching. Using the model, a problem of therapeutic effect in clinic is analyzed and a new therapy scheme is recommended. The scheme is proved to be effective in the clinic experiment.

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中图分类号:TP 391.9;R 318.51

所属栏目:生物医学光子学与激光医学

收稿日期:2005-09-07

修改稿日期:2006-01-08

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作者单位    点击查看

程刚:北京理工大学自动控制系 北京 100081
钟秋海:北京理工大学自动控制系 北京 100081
黄乃艳:解放军总医院激光科 北京 100853
顾瑛:解放军总医院激光科 北京 100853

联系人作者:程刚(chenggang@bit.edu.cn)

备注:程刚(1981—),男,河南焦作人,北京理工大学博士研究生,主要从事光动力治疗鲜红斑痣系统建模研究。

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