Chinese Optics Letters, 2005, 3 (12): 12705, Published Online: Jun. 6, 2006   

Raman spectroscopic identification of normal and malignant human stomach cells Download: 593次

Author Affiliations
Key Laboratory of Optical and Magnetic Resonance Spectroscopy (East China Normal University), Ministry of Education, Department of Physics, and Department of Chemistry, East China Normal University, Shanghai 200062
Abstract
Micro-Raman spectroscopy is employed to identify the normal and malignant human stomach cells. For the cancer cell, the reduced intensity of the Raman peak at 1250 cm^(-1) indicates that the protein secondary structure transforms from β-sheet or disordered structures to α-helical, while the increased intensity of the symmetric PO2 stretching vibration mode at 1094 cm^(-1) shows the increased DNA content. The ratio of the intensity at 1315 cm^(-1) to that at 1340 cm^(-1) reduces from 1.8 for the normal cell to 1.1 for the cancer cell in the course of canceration, and the ratio of the intensity at 1655 cm^(-1) to that at 1450 cm^(-1) increases from 1.00 for the cancer cell to 1.26 for the normal cell which indicates that the canceration of stomach cell may induce saturation of the lipid chain.

Jipeng Yang, Jianyu Guo, Liangping Wu, Zhenrong Sun, Weiying Cai, Zugeng Wang. Raman spectroscopic identification of normal and malignant human stomach cells[J]. Chinese Optics Letters, 2005, 3(12): 12705.

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