激光生物学报, 2004, 13 (3): 178, 网络出版: 2006-06-11
金属酞菁光敏剂的三阶非线性光学性能研究
Studies on the 3-order Optical Nonlinearity of the Photosensitizer of Phthalocyanines
酞菁 光敏剂三阶光学非线性 三线态量子产率和寿命 荧光显微成像系统 phthalocyanine the 3rd optical nonlinearity of photosensitizer quantum yield and lifetime of triplet state fluorescence microscopy imaging system
摘要
从光动力治疗癌症的疗效着眼研究酞菁配合物的三阶非线性光学性能.用时间分辨简并四波混频方法测量苯硫基钛菁锌(C56H32S4Zn),苯硫基铝酞菁(C56N32AlClN8S4)以及烷氧基铝酞菁(C56H32AlN8O4)的三阶非线性光极化率;测量四波混频响应的衰减过程;研究时间响应的超快过程和慢过程及其动力学机制,它们分别对应于单态和三线态的寿命.在荧光显微成像系统中观察三种酞菁光敏剂对人肝癌细胞杀伤的形态变化,并用MTT方法检测细胞存活率.对三种酞菁配合物的三线态量子产率和寿命进行测定,结果与它们对人肝癌细胞的光动力杀伤作用相关联.
Abstract
The 3-order optical nonlinearity of the photosensitizer of phthalocyanines was studied on the basis of photodynamic therapeutical effects. With the method of time-resolved DFWM, the 3-order optical nonlinear susceptibilities and the DFWM response profiles of (C_(56)H_(32)S_4Zn),C_(56)N_(32)AlClN_8S_4, and (C_(56)N_(32)AlClN_8O_4) were measured. Within the resolution of the optical pulse, the rise time of the nonlinear response is instantaneous and the dominant decay revealing both the rapid and the slow decay is ...
黄燕萍, 沈珊雄, 李琳, 李珊珊, 魏容慧, 祁春媛. 金属酞菁光敏剂的三阶非线性光学性能研究[J]. 激光生物学报, 2004, 13(3): 178. 黄燕萍, 沈珊雄, 李琳, 李珊珊, 魏容慧, 祁春媛. Studies on the 3-order Optical Nonlinearity of the Photosensitizer of Phthalocyanines[J]. Acta Laser Biology Sinica, 2004, 13(3): 178.
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