应用光纤探测系统和自行研制的光纤探针深度计, 成功实现了Kr⁺紫激光辐射新鲜离体人肺组织体表面漫反射率和内部光能流率分布的精确测定, 并利用漫射理论和加倍(Adding-Doubling)方法的部分结论, 获得了紫光人肺癌组织和正常组织的主要光学特性参数, 与蒙特卡罗法拟合实验的光分布曲线得出的结果一致。 为临床实际应用提供了重要的原始参数。

By using a “Depthometer with an isotropic fiber-optic probe” developed by the authors, the diffuse reflectance as well as the fluence rate distributions in the normal and cancerous human lung tissues irradiated by a collimated broad beam of a violet Kr⁺laser(406.7～415.4 nm) have been accurately measured. In combination with the diffusion theory and the Adding-Doubling technique, the optical characteristics of human lung tissues, such as the absorption and the reduced scattering coefficients, the penetration depth and the effective attenuation coefficient, were derived. The experimental data agree well with the fitting results by Monte Carlo simulations. It is believed that this original set of data on the optical parameters will be very useful for the lung cancer photodynamic diagnosis (PDD) and the light dosage designations.