A simple method based on CFD code and Matlab for aero-optic effects is presented. Density fluctuation from CFD code due to the changes of such factors as altitude, speed, equipment location, and wavelength is introduced as an input to Matlab. The overall calculations are in Matlab. The results show that the performance of electro-optical (EO) system can be improved when the altitude increasing, the speed is as slowly as possible, and the equipment location moves to the leading edge of the airborne platform as far as possible, for the wavelength there is an optimum one when the indexes of contrast and resolution of the system are both considered. All of these methods can minimize the optical aberrations. Several numerical simulations demonstrate the method.