Application of surface enhanced Raman scattering spectroscopy in rat serum
High signal-to-noise surface enhanced Raman scattering (SERS) signal of rat serum was obtained in this article. Two methods were presented to enhance the intensity of rat serum SERS signal. The novel colloid silver was synthesized using heating method by microwave and it was introduced to be the active site of SERS, "hot sites" could be detected in the active site. At same time the high numerical aperture (NA) oil immersed object lens was applied in micro-Raman system so that some new peaks come up in SERS spectrum of rat serum because of the evanescent wave was employed to excite the sample.
Shifa Wu：Institute of Near-Field Optics and Nanotechnology, Department of Physics, Dalian University of Technology, Dalian 116024
Yi Zhang：Institute of Near-Field Optics and Nanotechnology, Department of Physics, Dalian University of Technology, Dalian 116024
Hui Liu：College of Medical laboratory, Dalian Medical University, Dalian 116023
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Kun Liu, Shifa Wu, Yi Zhang, Hui Liu, "Application of surface enhanced Raman scattering spectroscopy in rat serum," Chinese Optics Letters 3(0s), 161-163 (2005)