Chinese Optics Letters, 2005, 3 (0s): 208, Published Online: Mar. 5, 2007  

Photo-stability of water-soluble quantum dots in living cells Download: 550次

Author Affiliations
1 Department of Physics, Fudan University, Shanghai 200433
2 State Key Lab for Advanced Photonic Materials and Devices, Fudan University, Shanghai 200433
3 Department of Macromolecular Science and Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433
Abstract
Hydrophilic photo luminescent semiconductor quantum dots (QDs) are novel nanometer-size probes, which may have potential using in bio-imaging for biological objects. In this work, the photo-stability of these QDs in two kinds of living cells was studied, compared with conventional biological probes such as fluorescein isothiocyanate (FITC) and green fluorescence protein (GFP). It was found that the concentration of QDs in living cells is the dominant factor for its photo-stability in biological environment. When the concentration of the intracellular QDs was high, the QDs show good photo-stability that is much better than the organic fluorescent probes. However when its concentration was low, the QDs also can be photo-bleached quickly. Thus the reaching of the certain concentration level is the critical condition for QDs in the application of bio-imaging.

Jiong Ma, Jiyao Chen, Jia Guo, Changchun Wang, Lei Xu, Peinan Wang. Photo-stability of water-soluble quantum dots in living cells[J]. Chinese Optics Letters, 2005, 3(0s): 208.

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