光学学报, 2007, 27 (6): 1071, 网络出版: 2007-06-08
基于三维简并四波混频的PDT光敏剂HA瞬态光栅特性研究
Transient-Grating of Hypocrellin in Photodynamic Theraphy Based on Three-Dimensional Degenerative Four-Wave Mixing
光学材料 光动力疗法 激发态分子内质子转移 三维简并四波混频 瞬态光栅 optical material photodynamic therapy excited-state intramolecule proton transfer three-dimensional degenerative four-wave mixing transient grating
摘要
竹红菌甲素(hypocrellin A,HA)具有丰富的激发态特性,有可能在新型光动力疗法(PDT)光敏剂、激光染料和新型光电器件方面有一定的应用前景。利用瞬态光栅技术研究了竹红菌甲素分别在不同极性和粘度溶剂中以及溶剂本身的瞬态光栅特性,把其瞬态光栅的超快过程归结为竹红菌甲素质子转移形成的过渡态TS*的衰减,得出过渡态TS*瞬态光栅的寿命为10.5 ps。竹红菌甲素分子的质子转移过渡态TS*瞬态光栅寿命不受溶剂极性和粘度的影响。
Abstract
Hypocrellin A (HA) has abundant electronic excited-state properties, and is probably used to new-style photosensitizer of photodynamic therapy, laser dye and novel photoelectron material. The transient-grating properties of hypocrellin A in solvent with different polarity and glutinosity and the solvent are studied with transient-grating technology. The ultrafast process of the transient grating results from the decay of transitional state (TS*) produced by hypocrellin A proton transfer. The lifespan of the transitional state (TS*) is 10.5 ps and is independent of polarity and glutinosity of the solvent.
高博文, 孟婧, 方芸, 王文国, 汤国庆. 基于三维简并四波混频的PDT光敏剂HA瞬态光栅特性研究[J]. 光学学报, 2007, 27(6): 1071. 高博文, 孟婧, 方芸, 王文国, 汤国庆. Transient-Grating of Hypocrellin in Photodynamic Theraphy Based on Three-Dimensional Degenerative Four-Wave Mixing[J]. Acta Optica Sinica, 2007, 27(6): 1071.
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