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Feasibility of photoacoustic tomography for ophthalmology

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Abstract

For the eyeball composed of membrane and liquid, the contrast of ultrasound imaging is not high due to its small variance in acoustic impedance. As a new imaging modality, photoacoustic tomography combines the advantages of pure optical and ultrasonic imaging together and can provide high resolution, high contrast images. In this paper, the feasibility of photoacoustic tomography for ophthalmology is studied experimentally. A Q-switched Nd:YAG pulsed laser with 7-ns pulse width is used to generate photoacoustic signal of a porcine eyeball in vitro. The two-dimensional (2D) optical absorption image of the entire eyeball is reconstructed by time-domain spherical back projection algorithm. The imaging results agree well with the histological structure of the eyeball and show a high imaging contrast.

Newport宣传-MKS新实验室计划
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收稿日期:2006-12-07

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作者单位    点击查看

卢涛:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
Tao Lu:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
宋智源:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
Zhiyuan Song:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
苏翼雄:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
Yixiong Su:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
张帆:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
Fan Zhang:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
姚建铨:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072
Jianquan Yao:Institute of Lasers and Optoelectronics, College of Precision Instrument and Opto-Electronics Engineering, Tianjin University, Tianjin 300072

备注:T. Lu's e-mail address is tjulutao@yahoo.com.cn.

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