中国激光, 1995, 22 (4): 316, 网络出版: 2007-08-17
金蒸气激光光敏疗法治疗膀胱癌的临床研究
Photodynamic Therapy of Bladder Cancer with a Gold Vapour Laser
摘要
报道经多种治疗后再生的膀胱癌患者70例,共316个肿瘤,用光纤输出功率2 W,带有球型弥散刀头石英光纤传输的金蒸气激光,通过膀胱镜作肿瘤及全膀胱血卟啉光敏治疗,经6~46个月的随访,痊愈54例,占77.14%,显效12例占17.14%,好转4例,占5.7%,再生8例,占11.43%。
Abstract
Seventy patients with 316 tumors of urinary bladder have been treated by photodynamic therapy (PDT) with a gold vapour laser. All cases were histopathologically diagnosed as transitional cell carcinoma. The power output from the tip of an optic fibre was 2.0~2.5 W and the power density used was 70.8~509.6 mW/cm2. The pulse duration was 20~50 μs, the pulse energy was 0.5 mJ per pulse and the repetition rate was of 6000~9000 Hz. Both the tumors and whole bladder were irradiated. Hematoporphyrin derivative (HpD, Yanzhou Biochemical Pharmaceutics, China was given IV in a dose of 5 mg/kg in 250 ml of 5% glucose, 48 hours prior to irradiation. The results of a follow-up of 4~46 months are as follows: cured, 54 case (77.14%); good effect, 12 (17.14%); and improved, 4(5.7%). Tumor regrowth occurred only in 8 cases (11.43%) within 3~9 months after PDT. The results suggest an increase of cured ratio and a decrease of regrowth ratio and the reoccurrence ratio of tumors has compared with results obtained by other treatment modalities.
朱菁, 张慧国, 朱邦鉴, 戴胜国, 吴家骏, 江鱼. 金蒸气激光光敏疗法治疗膀胱癌的临床研究[J]. 中国激光, 1995, 22(4): 316. 朱菁, 张慧国, 朱邦鉴, 戴胜国, 吴家骏, 江鱼. Photodynamic Therapy of Bladder Cancer with a Gold Vapour Laser[J]. Chinese Journal of Lasers, 1995, 22(4): 316.