光散射学报, 2008, 20 (1): 86, 网络出版: 2014-01-21
5-HT3受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究
Spectroscopic Analysis on 5-HT3 Receptor Antagonist Dolasetron Mesylate
甲磺酸多拉司琼 5-羟色胺受体拮抗剂 分子振动光谱 红外光谱 拉曼光谱 Dolastron mesylate 5-HT3 receptor antagonist Molecule vibration spectroscopy FTIR Raman
摘要
甲磺酸多拉司琼是5-羟色胺受体拮抗剂药物, 属于肿瘤化放治疗的辅助药物, 本文采用傅里叶变换红外光谱仪和激光拉曼光谱仪进行光谱检测, 对甲磺酸多拉司琼的拉曼光谱与红外光谱的差异进行分析, 对其分子振动光谱与结构特征相关进行分析和探讨, 从而为药物合成及质量控制提供了重要的参考价值。
Abstract
Dolasetron mesylate is a 5-HT3 receptor antagonist which is used on chemotherapy for the prophylaxis of nausea and vomiting. In this paper, the molecular vibration of dolasetron mesylate was detected and measured by FTIR and Raman spectroscopic analysis, the difference between Infrared and Raman characteristic group frequencies of dolasetron mesylate was discussed, and the molecule vibration was assigned and identified to associate characteristic frequencies with its characteristic structure. These experiment results provide more important information for pharmaceutical synthesis and quality control.
陈晓红, 张倩芝, 张卫红, 陈建. 5-HT3受体拮抗剂药物甲磺酸多拉司琼的分子光谱研究[J]. 光散射学报, 2008, 20(1): 86. CHEN Xiao-hong, ZHANG Qian-zhi, ZHANG Wei-hong, CHEN Jian. Spectroscopic Analysis on 5-HT3 Receptor Antagonist Dolasetron Mesylate[J]. The Journal of Light Scattering, 2008, 20(1): 86.