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激光照射参数对光动力学疗法治疗眼底病中视网膜温度影响的理论分析

Influence of Laser Parameters on Temperature Distribution of Retina:a Theoretical Analysis

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摘要

目的 了解不同激光照射参数对光动力学疗法治疗眼底疾病中视网膜温度的影响.方法 根据经典Pennis热传输方程建立视网膜温度分布的数学模型,理论分析激光波长、功率密度及光斑直径对光动力学疗法治疗过程中对青紫蓝灰兔视网膜温度的影响.结果 当照光剂量相同时,578 nm激光引起的灰兔视网膜温升最大,532 nm激光次之,690 nm激光最小;随着激光功率密度及光斑直径的增加,视网膜温升也越高.结论 光动力学疗法治疗中严格控制照光参数对于防止不必要的视网膜热损伤非常重要.

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中图分类号:TN249;R771

所属栏目:论著

基金项目:北京市自然科学基金(3072012)

收稿日期:2007-10-23

修改稿日期:--

网络出版日期:0001-01-01

作者单位    点击查看

陈虹霞:解放军总医院激光医学科,北京市,100853
顾瑛:解放军总医院激光医学科,北京市,100853
程刚:北京理工大学自动化控制系
刘凡光:解放军总医院激光医学科,北京市,100853
曾晶:解放军总医院激光医学科,北京市,100853

备注:陈虹霞(1973~),女,山东烟台人,医学博士,主要从事激光医学的基础与临床应用研究.

【1】Schmidt-Erfurth U,Hasan T.Mechanisms of action of pho-todynamic therapy with verteporfin for the treatment of age-related macular degeneration[J].Survey Ophthalmol,2000,45:195-214.

【2】Pennes HH.Analysis of tissue and arterial blood tempera-tures in the resting human forearm[J].J Appl Physiol,1948.1:93-122.

【3】Verkruysse W,Picketing JW,Beek JF,et al.Modelling the effect ofwavelength on the pulsed dye laser treatment of port wine stains[J].Appl Optics,1993,32:393-398.

【4】Thompson CR,Gerstman BS,Jacques SL,et al.Melanin granule model for laser-induced thermal damage in the reti-na[J].Bull Mathematl Biol,1996,58:513-553.

【5】Kim BM,Jacques SL,Rastegard S,et al.Nonlinear fi-nite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue[J].IEEE J Selected Topics Quant Electron,1996,2:922-933.

【6】Kluded ARA,Vafai K.The role ofporous media in model-ing flow and heat tral~fer in biological tissues[J].Int J Heat Mass Transfer,2003,46:4989-5003.

【7】Mones J.VIP Study Group:Photodynamic therapy(PDT) with verteporfin of subfoveal choroidal neovascularization in age-related macuhr degeneration:study design and base-line characteristics in the VIP randomized clinical trial[J].Invest Ophthalmol Vis Sei,1999,40:S321.

【8】Birngmber R,Hillenkamp F,Gabel VP.Theoretical in-vestigations of laser thermal retinal injury[J].Health Pllys,1985,48:781-796.

【9】Peyman GA,Genaidy M,Moshfeghi DM,et at.Transpu-pillary thermotherapy threshold parameters:funduscopic angiographic,and histologic findings in pigmented and nonpigmented rabbits[J].Retina,2003,23:371-385.

【10】Mainster MA,Reichel E.Transpupillary thermotherapy for age-related macular degeneration:long-pulsed photo-coagulation,apoptesis,and heat shock protein[J].Oph-thalmol Surg Lasers,2000,31:359-373.

引用该论文

陈虹霞,顾瑛,程刚,刘凡光,曾晶. Influence of Laser Parameters on Temperature Distribution of Retina:a Theoretical Analysis[J]. Chinese Journal of Laser Medicine & Surgery, 2008, 17(2): 89-93

陈虹霞,顾瑛,程刚,刘凡光,曾晶. 激光照射参数对光动力学疗法治疗眼底病中视网膜温度影响的理论分析[J]. 中国激光医学杂志, 2008, 17(2): 89-93

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