Chinese Optics Letters, 2009, 7 (1): 0160, Published Online: Mar. 4, 2009
Raman spectroscopic identification of normal and malignant hepatocytes Download: 794次
拉曼光谱 肝细胞癌 t-检验 主成分分析 线性判别分析 300.6450 Spectroscopy, Raman 170.5660 Raman spectroscopy 170.1530 Cell analysis
Abstract
Raman spectroscopy has strong potential for providing non-invasion diagnosis of cancers. In this paper, micro-Raman spectroscopy is used to diagnose one most common liver cancer, hepatocellular carcinoma (HCC). The statistical analyzes, including t-test, principal component analysis (PCA), and linear discriminant analysis (LDA), are performed on the Raman spectra of malignant and normal hepatocytes. The t-test-LDA results show that the 786- and 1004-cm^{-1} bands of the malignant and normal hepatocytes are significantly different, and PCA-LDA results show an overall accuracy of 100% for the Raman spectroscopic identification of normal and malignant hepatocytes in our experiment.
Jianyu Guo, Bing Du, Min Qian, Weiying Cai, Zugeng Wang, Zhenrong Sun. Raman spectroscopic identification of normal and malignant hepatocytes[J]. Chinese Optics Letters, 2009, 7(1): 0160.