中国激光, 2009, 36 (4): 1020, 网络出版: 2009-04-27
激光融血栓的光纤光栅监控实验研究
Experimental Research on Fiber Bragg Grating Based Monitor for Laser Thrombolysis in vitro
摘要
实验研究了光纤光栅(FBG)传感器在激光融血栓模拟过程中的监控作用。在激光融血栓模拟过程中,由于血液对激光的吸收,产生了空化气泡,气泡的产生和崩溃的过程中激发出了冲击波。光纤光栅传感系统以波长可调的半导体分布反馈(DFB)激光器为光源,采用边缘滤波解调的方式,实现了对冲击波的有效测量。实验中,冲击波响应峰值随融血栓激光功率的增加而上升。实验中还发现血栓消融后的血液中光纤光栅冲击波响应与没有血栓时的冲击波响应类似。根据这个类似性来判断血栓是否消融。模拟实验中测量到的激光融血栓时间为23s。
Abstract
The experimental investigation of the fiber Bragg grating (FBG) sensor in monitoring action for the laser thrombolysis is introduced. In laser thrombolysis, the pulsed laser is absorbed by blood, leading to cavitating bubbles. The shock wave is generated during bubble expansion and collapse. With a tunable distributed feed back (DFB) LD laser as the light source and an edge filtering demodulation, the shock wave was measured by FBG based sensing system. In experiment, the peak power of the shock wave response increases with the laser power, and the FBG responsibility for the shock wave in the blood after ablation of clot is similar to that in blood without clot. According to this similarity, whether the clot is ablated or not can be distinguished. In the in vitro experiment, the measured ablation time is 23 s.
陈哲敏, 陈军, 山下丰, 山下大浦, 清水良幸. 激光融血栓的光纤光栅监控实验研究[J]. 中国激光, 2009, 36(4): 1020. Chen Zhemin, Chen Jun, Yamashita Yutaka, Yamashita Daisuke, Shimizhu Yoshiyuki. Experimental Research on Fiber Bragg Grating Based Monitor for Laser Thrombolysis in vitro[J]. Chinese Journal of Lasers, 2009, 36(4): 1020.