中国激光, 2009, 36 (s1): 181, 网络出版: 2009-06-18
频域光学相干层析成像及其在眼科中的应用
Frequency-Domain Optical Coherent Tomograph and the Application in Ophthalmology
医用光学 光学相干层析 眼科 频域 视网膜 medical optics optical coherence tomography ophthalmology frequency-domain retina
摘要
光学相干层析成像(OCT)是一种具有高分辨率、非接触、非侵入的成像技术, 它通过测量生物组织的后向散射光的干涉信号, 对生物组织的内部结构进行层析成像。OCT技术作为一种诊断技术被广泛应用于医学领域, 特别是眼科图像诊断。由于频域OCT(FD-OCT)无需进行纵向扫描就可得到全部深度位置的特征信息, 因此成像速度比传统时域OCT(TD-OCT)快, 更适合于眼科应用。构建了一套基于光纤的频域光学相干层析成像系统, 纵向分辨率达到了10 μm, 扫描速度达到了每秒24000次以上。通过调节系统可对眼底视网膜成像, 实现临床诊断。
Abstract
Optical coherence tomography (OCT) is a high resolution, contact-free and non-invasive optical imaging approach. By measuring the interference signal of the backscattering light of the tissues, OCT can obtain the interior structure of the tissues. As a diagnostic technique, OCT has been widely used in medical examination, especially in ophthalmological imaging diagnosis. Frequency-domain OCT (FD-OCT) has a better performance in the imaging speed than that of time-domain OCT (TD-OCT), as it can obtain the characteristic information of the whole depth without mechanical scanning. Therefore, it is more applicable to ophthalmology. We constructed a fiber based FD-OCT imaging system, of which the axial resolution is less than 10 μm and scanning speed is more than 24000 times per second. The system can image the retinal tissue structure for clinical diagnosis.
王纬超, 刘宇嘉, Tobias Braeuler, 席鹏, 周传清, 江旻珊, 任秋实. 频域光学相干层析成像及其在眼科中的应用[J]. 中国激光, 2009, 36(s1): 181. Wang Weichao, Liu Yujia, Tobias Braeuler, Xi Peng, Zhou Chuanqing, Jiang Minshan, Ren Qiushi. Frequency-Domain Optical Coherent Tomograph and the Application in Ophthalmology[J]. Chinese Journal of Lasers, 2009, 36(s1): 181.