中国激光, 2009, 36 (10): 2534, 网络出版: 2009-10-23
单探测器偏振相干层析的生物组织成像
Single-Detector Polarization-Sensitive Optical Coherence Tomography for Biological Tissue Imaging
探测器 偏振光学相干层析技术 单探测器 偏振光 双折射 Monte Carlo 模拟 detectors polarization-sensitive optical coherence tomograph single-detector polarized light birefringence Monte Carlo simulation
摘要
主要研究了基于单探测器的偏振光学相干层析技术(PS-OCT),探索并验证其定性检测生物组织双折射性质的能力。论述了单探测器PS-OCT系统检测组织双折射性质的理论,并利用Monte Carlo方法模拟了双折射对Stokes矢量分布的影响。在此基础上,搭建了单探测器PS-OCT系统,系统的纵向分辨率可达10 μm。利用该系统对牛软骨组织进行成像实验,获得反映牛软骨双折射性质的组织图像。理论和实验结果均表明,基于单探测器的PS-OCT系统可以检测组织双折射性质的变化,能够应用于医学诊断组织病变。
Abstract
The single-detector polarization-sensitive optical coherence tomography (PS-OCT) is studied,aiming at validating its ability to detect qualitatively the birefringence of biological tissue. The theory of single-detector PS-OCT detecting the birefringence of biological tissue was described,and the influence of birefringence on the Stokes vector was demonstrated with Monte Carlo simulation. A single-detector PS-OCT system was set up,which has a theoretical resolution of 10 μm,and experiment was performed on a bovine cartilage sample. The PS-OCT image indicated the birefringence of cartilage. The theoretical analysis and experiments results prove the ability of single-detector PS-OCT detecting tissue birefringence and the possibility of using single-detector PS-OCT in medical diagnosing domain.
汪毅, 陈晓冬, 李海峰, 李乔, 郁道银. 单探测器偏振相干层析的生物组织成像[J]. 中国激光, 2009, 36(10): 2534. Wang Yi, Chen Xiaodong, Li Haifeng, Li Qiao, Yu Daoyin. Single-Detector Polarization-Sensitive Optical Coherence Tomography for Biological Tissue Imaging[J]. Chinese Journal of Lasers, 2009, 36(10): 2534.