中国激光, 2009, 36 (s2): 206, 网络出版: 2009-12-30
基于光学成像模型与Kubelka-Munk理论的皮肤光学参数测量
Optical Parameter of Skin Based on Optical Coherence Tomography Scattering Model and K-M Theory
医学光学与生物技术 散射系数 光学相干层析成像 库贝尔卡蒙克理论 皮肤 medical optics and biotechnology scattering coefficient optical coherence tomography Kubelka-Munk theory skin
摘要
结合光学相干层析成像(OCT)与Kubelka-Munk(K-M)理论定量分析不同年龄皮肤的光学参数的变化情况。以鼠龄分别为4周,20周和40周的小白鼠作为动物模型,使用OCT技术对其成像,通过活体测量小鼠皮肤组织OCT后向散射信号来反应皮肤内部的散射性质,利用OCT散射模型获得不同鼠龄散射系数的变化情况,并通过K-M理论测量法对不同生长期小鼠的皮肤进行离体测量,获得约化散射系数。利用OCT散射模型及K-M理论获得的散射系数与约化散射系数都是随着鼠龄的增加而增大,两种方法的结果是吻合的。结果显示OCT是一种很有潜力的检测活体老化皮肤的工具,为老化皮肤及皮肤美容的研究提供了理论基础。
Abstract
Optical coherence tomography (OCT) scattering model and Kubelka-Munk (K-M) theory are combined to analyze the changes of optical parameter quantitively in different aging skin in this paper. In the concrete,the Kun-ming mice with 4 weeks,20 weeks and 40 weeks respective are taken as animal model which imaged by OCT system,the scattering property in mouse skin is responded by OCT backscattering signal in vivo. And the changes of scattering coefficient are gotten by OCT scattering model,and then K-M theory equipment is used to obtain the reduced scattering coefficient in vitro. The outcome indicates that the trends of scattering coefficient obtained from OCT scattering model and the reduced scattering coefficient gotten from the K-M theory in aging mouse skin are uniform,which increases with ages. This result demonstrates that OCT can become a potential tool for detecting the aging skin in clinic in the future,which provides the theoretical basis for studying aging skin and skin cosmetology.
吴淑莲, 李晖, 李志芳, 蔡吓妹, 谢文明. 基于光学成像模型与Kubelka-Munk理论的皮肤光学参数测量[J]. 中国激光, 2009, 36(s2): 206. Wu Shulian, Li Hui, Li Zhifang, Cai Xiamei, Xie Wenming. Optical Parameter of Skin Based on Optical Coherence Tomography Scattering Model and K-M Theory[J]. Chinese Journal of Lasers, 2009, 36(s2): 206.
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