目的:观察CO₂激光与Ho:YAG激光联合应用治疗头面部角化棘皮瘤的疗效。方法:对2001年1月~2007年12月收治的7例头面部角化棘皮瘤患者采用CO₂激光和Ho:YAG激光联合治疗,观察其临床效果。结果:7例患者1次治愈6例,1次治愈率85.7％;2次治愈1例,2次冶愈率14.3％;总有效率100％。术后外形恢复满意。结论:对于直径小于1.5cm的早期的头面部角化棘皮瘤患者,Ho:YAG激光与CO₂激光联合治疗术中出血少,治疗效果好。由于角化棘皮瘤迅速增长的性质及与鳞癌的不确定关系,我们认为头面部角化棘皮瘤应尽早干预,以取得良好的结果。

Objective: To discuss the curative effect of craniofacial keratocanthoma (KA) which combine CO₂ laser with Ho: YAG laser. Methods: From February 2001 to December 2007,7 patients with craniofacial KA were treated by a CO₂ laser combined with Ho:YAG laser. Results: 6 out of the 7 KA patients were cured after one surgery,1 was cured after a second laser intervention. The cure rate was 85.7% and 14.3% respectively. All the patients were satisfactory with the appearance after surgery. The wound healing was good and the recovery profile was satisfactory after operation. Conclusion: Combination of CO₂ laser and Ho: YAG laser in treating early KA which is smaller than 1.5cm in diameter is effective and has a contribution in less bleeding. Because of the aggressive nature and uncertain relationship to squamous cell carcinoma,we recommend that early complete excision by the laser operation is the treatment of choice for craniofacial KA,which may provides good results and a very low risk of recurrence.