光学 精密工程, 2009, 17 (10): 2465, 网络出版: 2010-08-31   

多通道柔性神经微电极加工工艺

Microfabrication of multichannel flexible neural microelectrodes
作者单位
1 上海交通大学 生命科学技术学院,上海 200240
2 上海大学理学院 纳微能源研究所,上海 200444
3 上海交通大学 微纳科学技术研究院, 上海 200240
4 中国科学院 上海微系统与信息技术研究所, 上海 200050
摘要
针对多通道柔性神经微电极的设计及制作,研究了微电极的加工工艺。采用一种新型的柔性聚合物材料——聚对二甲苯(parylene C)作为微电极的基底和绝缘材料,借助微细加工技术,制作了36通道(按6×6矩阵排列)的柔性神经微电极,微电极的尺寸分别为Φ150 μm(圆形)和150 μm×150 μm(方形),电极引线线宽为30 μm。无论微电极为圆形或方形,表面均平整光滑、轮廓清晰。电学性能测试结果表明,1 kHz时微电极的阻抗仅为7 kΩ左右,且随着频率的增加,阻抗逐渐降低,呈明显高通特性。微电极加工质量较好,电学性能优良,实现了微电极和柔性基底的集成,有利于高效率批量制作,为视觉假体中柔性神经接口的研制奠定了基础。
Abstract
Multichannel flexible neural microelectrodes were designed and fabricated,and their fabrication processes were also studied. A microfabrication technology was introduced to manufacture flexible microelectrodes based on a new flexible substrate material, parylene C, due to its excellent electrical insulating, mechanical and biocompatible properties,and a 36-channel flexible neural microelectrode was fabricated with the arrangement in a 6×6 square grid pattern. The size of microelectrode was Φ150 μm (circular) and 150 μm×150 μm (squre), respectively,and the line width of metal trace was 30 μm. It was found that the microelectrode shows a smooth surface and a distinct outline.A electrtical test indicates that the impedance of microelectrode is only 7 kΩ or so, and it reduceds as frequency increasing, which is an excellent high-pass behavior.Moreover, the microelectrode and a flexible substrate can be integrated by the microfabrication technology.The microelectrode is suitable for the application in retinal prostheses, for it has a good quality and excellent electrical properties.

邢玉梅, 惠春, 徐爱兰, 李刚, 赵建龙, 任秋实. 多通道柔性神经微电极加工工艺[J]. 光学 精密工程, 2009, 17(10): 2465. XING Yu-mei, HUI Chun, XU Ai-lan, LI Gang, ZHAO Jian-long, REN Qiu-shi. Microfabrication of multichannel flexible neural microelectrodes[J]. Optics and Precision Engineering, 2009, 17(10): 2465.

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