Chinese Optics Letters, 2010, 8 (10): 950, Published Online: Oct. 19, 2010  

Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis Download: 802次

Author Affiliations
1 MOE Key Laboratory of Laser Life Science &
2 Institute of Laser Life Science, South China Normal University, Guangzhou 510631, China
Abstract
Bim, a proapoptotic member of Bcl-2 family, plays an important role in cell apoptosis. It is generally thought that Bim translocates to mitochondria in response to apoptotic stimuli. We use confocal microscopy to image the temporal-spatial dynamics of Bim during dihydroartemisinin (DHA) induced human lung adenocarcinoma (ASTC-a-1) cell apoptosis. Interestingly, we find that DHA induces Bim translocation to endoplasmic reticulum (ER) rather than mitochondria, implying that Bim-ER pathway might be involved in the DHA-induced ASTC-a-1 cell apoptosis.

Min Chen, Yingying Lu, Tongsheng Chen, Junle Qu. Confocal imaging of Bim translocation to endoplasmic reticulum during DHA-induced ASTC-a-1 cell apoptosis[J]. Chinese Optics Letters, 2010, 8(10): 950.

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