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Laser Immunotherapy: Novel Modality to Treat Cancer through Specific Antitumor Immune Response

Laser Immunotherapy: Novel Modality to Treat Cancer through Specific Antitumor Immune Response

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Abstract

Treatment of metastatic cancer remains a great challenge and needs novel approaches. Combining a selective photothermal therapy with an active immunological stimulation, laser immunotherapy (LIT) was developed to induce systemic immune responses through local intervention. LIT consists of three major components: a near-infrared laser, a light-absorbing agent, and an immunological stimulant. Its effect relies on two major interactions: a selective photothermal interaction and an active immunological stimulation. The selective photothermal interaction can reduce the tumor burden and at the same time release the tumor antigens, which can induce specific antitumor immune response. The expression of heat shock protein and the application of immunoadjuvant further enhance the host immunity. It has been proved in pre-clinical studies that LIT could not only eradicate treated local tumors but also regress and eliminate untreated metastases at distant sites. Moreover, LIT is well tolerated and has shown to have many advantages for cancer treatment compared with other traditional modalities.

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中图分类号:R730.57

DOI:10.3788/cjl20103711.2698

所属栏目:生物医学光子学与激光医学

基金项目:This research is supported in part by the US National Institutes of Health (P20 PR016478 from the INBRE Program of the National Center for Research Resources)

收稿日期:2010-06-28

修改稿日期:2010-08-18

网络出版日期:0001-01-01

作者单位    点击查看

Xiaosong Li:Department of Oncology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, ChinaDepartment of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA
Wei R. Chen:Department of Engineering and Physics, University of Central Oklahoma, Edmond, Oklahoma 73034, USA

联系人作者:Xiaosong Li(lixiaosong@hotmail.com)

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引用该论文

Xiaosong Li,Wei R. Chen. Laser Immunotherapy: Novel Modality to Treat Cancer through Specific Antitumor Immune Response[J]. Chinese Journal of Lasers, 2010, 37(11): 2698-2702

Xiaosong Li,Wei R. Chen. Laser Immunotherapy: Novel Modality to Treat Cancer through Specific Antitumor Immune Response[J]. 中国激光, 2010, 37(11): 2698-2702

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