光学相干层析术(optical coherence tomography, 简称OCT)具有非侵入性, 高分辨及高速成像的优点, 特别适合于生物医学领域. 但由于大部分生物组织具高散射系数, 通常仅能对表层组织下数毫米深度内进行成像. 穿透深度不足限制了OCT在皮肤科等领域应用. 作为常见多发病的鲜红斑痣具有病变组织浅, 血管增生明显等特点, 所以OCT非常适于鲜红斑痣的检测. 通过选择皮肤穿透性好的中心波长为1310nm超辐射二极管, 合理优化样品臂和参考臂光强比例及偏振控制, 实现了对鲜红斑痣在体成像研究, 采集了清晰的OCT图像, 得到其关键特征参数, 如表皮层厚度, 血管直径等, 对鲜红斑痣的诊断及制定合理治疗方案具有重要意义.

Optical coherence tomography is an appropriate imaging method for biomedical science, due to its advantages of noninvasive nature, high resolution and fast imaging speed. Because most biological tissues have the characteristic of high scattering coefficient, OCT system can just obtain the structural images several millimeters below the surface of the tissues. The superficial depth of OCT’s penetration limits application in dermatology field. As a common disease, the port wine stain (PWS) is a indication of OCT, because of its superficial lesion and significant expansion of blood vessels. To get deeper penetration in the skin, the authors employed 1 310 nm superluminescent diode as light source, optimized the light intensity ratio of reference delay arm and sample arm and control polarization, and the research of PWS imaging in vivo was accomplished. Besides, OCT is able to gather clear image and key characteristic parameters, such as the depth of epidermis layer, the diameter of blood vessel, etc. OCT will play an important role in the diagnosis and therapy of PWS.