光谱学与光谱分析, 2011, 31 (9): 2476, 网络出版: 2011-11-09  

双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析

Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal
作者单位
1 河北医科大学药学院, 河北 石家庄050017
2 北京市太赫兹谱重点实验室, 首都师范大学物理学院, 北京100048
摘要
药物共晶是改善药物活性成分(API)的物理化学特性的新技术和新思维, 具有很大的应用潜力。 本实验采用研磨法制备了双苯氟嗪盐酸盐(DF-HCl)和苯甲酸的共晶, 应用红外光谱(IR)、 拉曼光谱(Raman)、 差示扫描量热分析(DSC)、 X射线衍射(XRD)和太赫兹光谱(THz)对共晶进行了表征。 结果表明: 双苯氟嗪盐酸盐与苯甲酸之间形成共晶分子, 太赫兹谱的研究进一步表明两种分子之间有氢键形成。
Abstract
Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient (API), which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates (pseudo-polymorphs). In our study, dipfluzine hydrochloride-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.

杨彩琴, 王静, 张振伟. 双苯氟嗪盐酸盐和苯甲酸的共晶制备和谱学分析[J]. 光谱学与光谱分析, 2011, 31(9): 2476. YANG Cai-qin, WANG Jing, ZHANG Zhen-wei. Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal[J]. Spectroscopy and Spectral Analysis, 2011, 31(9): 2476.

关于本站 Cookie 的使用提示

中国光学期刊网使用基于 cookie 的技术来更好地为您提供各项服务,点击此处了解我们的隐私策略。 如您需继续使用本网站,请您授权我们使用本地 cookie 来保存部分信息。
全站搜索
您最值得信赖的光电行业旗舰网络服务平台!