利用富集分离方法， 克服高浓度基体对铅浓度及铅同位素测定的影响。 应用专利方法对模拟全血基体中的铅进行富集分离， 用ICP-MS测定富集分离前后的铅浓度、 基体浓度及铅同位素比值。 富集分离后的铅回收率均在99%以上， 对Na和K等主要离子的去除率约为80%； 各个铅同位素的浓度值随着基体浓度的增大而减小（p<0.001）， 但铅各同位素的比值则与基体浓度无关； 当基体浓度>62.5 μg·mL-1时， 各个铅同位素强度会随着测定次数的增加而迅速衰减。 富集分离专利方法对复杂基体中痕量铅的回收率高， 对杂质离子的去除率较好； 明显消除了高浓度基体对ICP-MS进样系统的堵塞现象， 操作简便、 成本低、 引入污染少， 可以提高各个铅同位素浓度测定的准确度和精密度， 且对铅同位素比值测定准确度无明显影响。

The enrichment and separation method was used in the present paper to overcome the influence of matrix effect on the determination of lead concentration and isotope ratios. The patented method was used to enrich and separate the lead in simulated blood matrix; the lead concentrations and isotope ratios were determined by ICP-MS before and after enrichment and separation. The recovery rate of Pb is more than 99% through this method while the removal rate of major impurity ions such as Na, K is about 80%. The concentrations of each lead isotope decrease with the matrix concentration increasing (p<0.001), and lead isotope ratios show no significant differences in the matrix of different concentrations. When the matrix concentration is more than 62.5 μg·mL-1, the strength will decrease with the determination times increasing. It was concluded that the characteristics of this method are of high recovery rate (>99%), fast, simple and convenient, and it can raise the accuracy and precision of the concentration determination of lead isotopes and has no significant influence on the accuracy of lead isotope ratios determination.