目的: 探讨抗代谢药物环孢霉素A对于抑制泪道激光成形术后纤维组织增生的作用, 指导临床用药, 以减少KTP激光治疗泪道阻塞的复发。方法: 制作成年家兔泪道狭窄动物模型后, 行KTP激光术后将其随机分成两组, 分别注入环孢霉素A和生理盐水, 观察泪道阻塞情况, 比较各组对于抑制泪道激光成形术后纤维组织增生的作用。结果: 环孢霉素A组较生理盐水组泪道狭窄出现时间晚, 纤维组织增生及胶原化程度轻。结论: 环孢霉素A能减轻泪道激光成形术后的纤维组织增生, 从而提高泪道激光成形术的治愈率。

Objective: Investigating the effect of CsA for reducing fibrous tissue hyperplasia after KTP Nd∶YAG laser recanalisation, guide the clinical use of medicine to reduce lacrimal duct stenosis relapse. Method: Making the animal model of lacrimal duct obstruction, dividing them into two groups, and injecting saline solution and CsA separately. Result: The appearance of lacrimal duct part obstruction and fibrous tissue hyperplasia is later in the CsA group, and the fibrous tissue hyperplasia is lighter. Conclusion: CsA can reduce fibrous tissue hyperplasia after KTP Nd: YAG, and improve the success rate of KTP Nd: YAG laser recanalization.