光学学报, 2013, 33 (11): 1117001, 网络出版: 2013-10-20   

利用人体组织液进行近红外无创血糖测量 下载: 655次

Noninvasive Blood Glucose Sensing with Near-Infrared Spectroscopy Based on Interstitial Fluid
作者单位
1 中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室, 吉林 长春 130033
2 中国科学院大学, 北京 100049
摘要
提出了一种利用人体皮肤组织液进行近红外无创血糖检测的新方法。通过细化人体表层皮肤组织模型,将真皮层上层含有少量血液的乳突层与真皮层下层区分开,并与表皮层共同作为探测对象;选择人体表皮层较厚的腕曲侧部作为检测部位;在此基础上利用蒙特卡罗方法计算了1680 nm(葡萄糖倍频吸收峰)近红外光在人体腕曲侧部皮肤组织模型中的平均最大穿透深度、主要吸收区域、平均光程、出射能量、各层皮肤组织吸收能量占比。结果显示,当光源到探测器探头距离为0.6 mm时,真皮层和角质层吸收的能量较少,光程适中,平均探测深度、主要吸收位置均位于乳突层中,因而此距离为最佳距离,并设计了光纤探头。通过以上方式避开了富含血液的真皮层下层的干扰,获取了表皮层和乳突层中组织液的光谱信息,有利于血糖的近红外无创测量,为后续工作提供了理论依据。
Abstract
A new near-infrared noninvasive method of detecting the glucose from human skin tissue interstitial fluid is presented. The skin tissue structure is refined, and the papillary layer containing a small amount of blood separated from the lower area of the dermal layer and the surface layer are used as the main objects. The wrist curved side is selected as the detecting part. And the average probe depth, the main absorption position, the average photon path length, the outputting energy and the fraction of absorbed energy in each skin tissue layer are calculated by the Monte Carlo method based on the above. The results show that both the average probe depth and the main absorption area are located in the papillary layer. The average photon path length is long enough and less energy is absorbed by the stratum corneum and the dermis when the distance between detector and the source is 0.6 mm. Thus the optimum source-detector distance of 0.6 mm is determined and the optical fiber detector is designed. The uniqueness of the method is that the spectral information from the epidermis and papillary is captured without the interference from the rich blood containing lower dermis, which is good for the near-infrared noninvasive blood glucose detection and provides a theoretical basis for the follow-up work.

吴春阳, 卢启鹏, 丁海泉, 高洪智. 利用人体组织液进行近红外无创血糖测量[J]. 光学学报, 2013, 33(11): 1117001. Wu Chunyang, Lu Qipeng, Ding Haiquan, Gao Hongzhi. Noninvasive Blood Glucose Sensing with Near-Infrared Spectroscopy Based on Interstitial Fluid[J]. Acta Optica Sinica, 2013, 33(11): 1117001.

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