Chinese Optics Letters, 2014, 12 (3): 031701, Published Online: Mar. 17, 2014  

Influence of laser power density on damage of comb by photodynamic therapy—simulation and validation of mathematical models

Author Affiliations
Abstract
Photodynamic therapy (PDT) has poor therapeutic outcomes for the treatment of port-wine stain (PWS) lesions with long drug-light intervals (DLIs). This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations (1O2). Both simulation and experimental results show that increasing the power density from 100 to 140 mW/cm2 not only improves the PDT efficacy, but also results in the unwanted skin damage.

Naiyan Huang, Zhongshun Ma, Ying Wang, Jing Zeng, Haixia Qiu, Xiaoying Tang, Ying Gu. Influence of laser power density on damage of comb by photodynamic therapy—simulation and validation of mathematical models[J]. Chinese Optics Letters, 2014, 12(3): 031701.

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