首页 > 论文 > Chinese Optics Letters > 12卷 > 3期(p:031701)

Influence of laser power density on damage of comb by photodynamic therapy—simulation and validation of mathematical models

  • 摘要
  • 论文信息
  • 参考文献
  • 被引情况
  • PDF全文
分享:

Abstract

Photodynamic therapy (PDT) has poor therapeutic outcomes for the treatment of port-wine stain (PWS) lesions with long drug-light intervals (DLIs). This letter investigates the possibility of improving the treatment efficacy through increasing the laser power density using a computer simulation and a cock comb model. The computational model includes a Monte Carlo simulation for the laser distribution and a calculation of the singlet oxygen concentrations (1O2). Both simulation and experimental results show that increasing the power density from 100 to 140 mW/cm2 not only improves the PDT efficacy, but also results in the unwanted skin damage.

中国激光微信矩阵
补充资料

DOI:10.3788/col201412.031701

所属栏目:Medical optics and biotechnology

责任编辑:刘盛龄

收稿日期:2013-09-25

录用日期:2014-01-15

网络出版日期:2014-02-28

联系人作者:联系作者(guyinglaser@sina.com)

备注:This work was supported by the Key Program of National Natural Science Foundation of China (No.61036014) and the National Natural Science Foundation of China (No. 31170963).

【1】L. Winer and B. Hills, Califor Med. 77, 242 (1952).

【2】C. J. Chang, J. S. Yu, and J. S. Nelson, J. Formos Med. Assoc. 107, 559 (2008).

【3】A. Orenstein, J. S. Nelson, L. H. Liaw, R. Kaplan, S. Kimel, and M. W. Berns, Lasers Surg. Med. 10, 334 (1990).

【4】Y. Gu, N. Huang, J. Liang, Y. M. Pan, and F. G. Liu, Ann. Dermatol. Venereol. 134, 241 (2007).

【5】Z. Huang, Photodiagn. Photodyn. Therapy 3, 71 (2006).

【6】Y. Zhao, Z. Zhou, G. Zhou, P. Tu, Q. Zheng, J. Tao, Y. Gu, and X. Zhu, Photoderm, Photoimmun Photomed 27, 17 (2011).

【7】K. Yuan, Q. Li, W. L. Yu, D. Zeng, C. Zhang, and Z. Huang, Photodiagn. Photodyn. Therapy 5, 50 (2008).

【8】E. Buytaert, M. Dewaele, and P. Agostinis, Biochim. Biophys. Acta Rev. Cancer 1776, 86 (2007).

【9】B. Chen, B. W. Pogue, P. J. Hoopes, and T. Hasan, Crit. Rev. Eukar. Gene Express 16, 279 (2006).

【10】N. Huang, G. Cheng, X. Li, Y. Gu, F. Liu, Q. Zhong, Y. Wang, J. Zen, H. Qiu, and H. Chen, Photodiagn. Photodyn. Therapy 5, 120 (2008).

【11】R. Valentine, K. Wood, C. Brown, S. Ibbotson, and H. Moseley, Phys. Med. Biol. 57, 6327 (2012).

【12】C. Zhu and Q. Liu, J. Biomed. Opt. 18, 050902 (2013).

【13】L. Wang, S. L. Jacques, and L. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995).

【14】S. L. Jacques, "Skin Optics," Oregon Medical Laser Center News, http://omlc.ogi.edu/news/jan98/skinoptics.html (1998).

【15】S. H. Tseng, P. Bargo, A. Durkin, and N. Kollias, Opt. Express 17, 14599 (2009).

【16】R. Chen, Z. Huang, H. Lui, I. Hamzavi, D. I.McLean, S. Xie, and H. Zeng, J. Photochem. Photobiol. B 86, 219 (2007).

【17】M. Friebel, A. Roggan, G.Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006).

【18】J. Chen, Y. Lu, S. Chen, and H. Cai, Photogr. Sci. Photochem. 9, 156 (1991).

【19】I. Georgakoudi, M. G. Nichols, and T. H. Foster, Photochem. Photobiol. 65, 135 (1997).

【20】N. Huang, Y. Gu, F. Liu, G. Cheng, Q. Zhong, Y. Wang, H. Qiu, L. Liu, and J. Zeng, in Proceedings of IEEE Conference on International Conference on Complex Medical Engineering 1172 (2007).

【21】K. K. H. Wang, S. Mitra, and T. H. Foster, Med. Phys. 34, 282 (2007).

【22】M. Nichols and T. Foster, Phys. Med. Biol. 39, 2161 (1994).

【23】T. H. Foster, R. S.Murant, R. G. Bryant, R. S. Knox, S. L. Gibson, and R. Hilf, Radiat. Res. 126, 296 (1991).

【24】B. Liu, T. J. Farrell, and M. S. Patterson, Phys. Med. Biol. 55, 5913 (2010).

【25】B. Liu, T. J. Farrell, and M. S. Patterson, J. Biomed. Opt. 17, 0880011 (2012).

【26】W. Cai and L. Ma, Chin. Opt. Lett. 10, 012901 (2012).

【27】B. Li, H. Lin, D. Chen, M. Wang, and S. Xie, Chin. Opt. Lett. 8, 86 (2010).

【28】N. Huang, G. Cheng, Y. Wang, J. Zeng, H. Qiu, and Y. Gu, Lasers Med. Sci. 26, 665 (2011).

【29】Y. Wang, Y. Gu, Z. Zuo, and N. Huang, J. Biomed. Opt. 16, 098001 (2011).

引用该论文

Naiyan Huang, Zhongshun Ma, Ying Wang, Jing Zeng, Haixia Qiu, Xiaoying Tang, Ying Gu, "Influence of laser power density on damage of comb by photodynamic therapy—simulation and validation of mathematical models," Chinese Optics Letters 12(3), 031701 (2014)

您的浏览器不支持PDF插件,请使用最新的(Chrome/Fire Fox等)浏览器.或者您还可以点击此处下载该论文PDF