目前临床上血氧饱和度的无创检测主要基于双波长的脉搏血氧饱和度测量原理, 但其检测精度仍然需要进一步的探究和完善。 近年来, 国内外的很多研究者采用三波长甚至八波长的方法测量血氧饱和度, 从某种程度上减小了误差。 动态光谱法作为一种新型血液成分无创检测方法, 能消除受试者个体差异和测量环境等的影响, 在血红蛋白浓度的无创检测研究中取得了很好的效果。 基于动态光谱法对多波长下脉搏血氧饱和度检测进行了研究: 对60名重症监护患者进行动态光谱采集以及动脉抽血分析血氧饱和度值; 采用高灵敏度光纤光谱仪, 采集受试者指端透射多波长下的光谱信息; 以单拍提取法提取波长范围为606.44~987.55 nm的动态光谱; 以动脉血气分析中血氧饱和度值为参考真值, 建立血氧饱和度与多波长动态光谱数据的组合间隔偏最小二乘校正模型; 得到预测集的相对误差为±0.017 6, 而两波长测量装置监护仪上得到的数据相对误差为±0.116 4。 结果表明: 利用高灵敏度光纤光谱仪采集多波长光谱信息, 用动态光谱法进行数据预处理, 进行多波长血氧饱和度检测, 有效降低了血氧饱和度的测量误差。

The present paper puts forward multi-wavelength pulse oxygen saturation measurement based on dynamic spectroscopy to do the non-invasive determination of oxygen saturation. Compared to conventional ways, the new method makes full use of more wavelengths light and improves the measurement accuracy. During the experiment, the in-vivo measurements were carried out on 60 patients and their spectroscopic data were collected by the high sensitivity type fiber optic spectrometer. Single-trial estimation method was used to extract the dynamic spectroscopy at the wavelengths of 606.44~987.55 nm. Oxygen saturation obtained from arterial blood gas analysis is regarded as the true value. Synergy interval partial least square (siPLS) was used to establish the calibration model of subjects’ oxygen saturation values against dynamic spectroscopy data. The relative error of prediction is ±0.017 6, but the relative error of the subjects in the same set measured by the patient monitor which was two-wavelength measure system is ±0.116 4. Measurement results show that the use of the high sensitivity type fiber optic spectrometer to collect multi-wavelength spectroscopic data and dynamic spectroscopy method to process data can do better in improving the accuracy of the oxygen saturation measurement.