Chinese Optics Letters, 2014, 12 (5): 051704, Published Online: May. 6, 2014
In vivo photoacoustic chorioretinal vascular imaging in albino mouse Download: 602次
170.5120 Photoacoustic imaging 170.4470 Ophthalmology 170.0110 Imaging systems 170.4500 Optical coherence tomography
Abstract
Photoacoustic ophthalmoscopy (PAOM) is a novel imaging modality, which is capable of non-invasively detecting optical absorption properties in the retina. We visualize the microvasculature in retina and choroid in albino mouse using PAOM guided by spectral-domain optical coherence tomography. Since albino mouse characterizes by lacking melanin in retinal pigment epithelium (RPE), PAOM illumination laser can penetrate through the RPE onto choroid, and consequently provides volumetric visualization of chorioretinal vasculatures as a result of strong hemoglobin optical absorption. The high-quality chorioretinal microvascular imaging acquired by PAOM implies its great potential in understanding pathological mechanisms and developing therapeutic strategies for major chorioretinal diseases that correlate with vascular disorders.
Wei Song, Qing Wei, Rui Zhang, Hao F.. In vivo photoacoustic chorioretinal vascular imaging in albino mouse[J]. Chinese Optics Letters, 2014, 12(5): 051704.