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Analysis of colonic autofluorescence spectra using multivariate curve resolution alternating least squares

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Abstract

Autofluorescence (AF) spectra of colonic normal and adenocarcinoma tissues are measured under excitation of 337 nm and analyzed by multivariate curve resolution alternating least squares (MCR-ALS) method using non-negativity constraint. Collagen, nicotinamide adenine dinucleotide hydrate (NADH) and elastin are identified as the main contributing biomedical components. Fisher’s discrminant anlysis (FDA) on the concentration profiles of the principle components (PCs) shows acceptable sensitivity, specificty and accuracy for discrminanting the adenocarcinoma tissues from the normal tissues. MCR-ALS is a powerful tool for characterzing the spectra profiles of the main biochemical components in neoplasm transformation.

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DOI:10.3788/col201412.051705

所属栏目:Medical optics and biotechnology

责任编辑:刘盛龄

收稿日期:2014-01-27

录用日期:2014-03-27

网络出版日期:2014-04-30

联系人作者:联系作者(bhli@fjnu.edu.cn)

备注:This work was supported by the Fujian Provincial Science and Technology Foundation (No. 2009Y0015), the Program for New Century Excellent Talents in University of China (No. NCET-10-0012), and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1115).

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引用该论文

Lina Liu, Changshun Yang, Weihua Li, Buhong Li, Shusen Xie, "Analysis of colonic autofluorescence spectra using multivariate curve resolution alternating least squares," Chinese Optics Letters 12(5), 051705 (2014)

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