光学学报, 2014, 34 (10): 1011004, 网络出版: 2014-08-26
抑制眼内杂散光提高视网膜成像质量方法研究
Inhibiting Intraocular Stray Light Method to Improve Quality of Retinal Image
自适应光学 微血管成像 杂散光 偏振光 1 m-1视标 adaptive optics micro-vascular imaging intraocular stray light polarized light with focal length of 1 m sighting target
摘要
利用液晶空间光调制器和夏克哈特曼探测器为核心器件搭建了一套液晶自适应光学(AO)视网膜成像系统。通过计算哈特曼光斑图和视网膜图像的调制传递函数(MTF)定量分析了眼内杂散光对视网膜成像质量的影响,结果表明哈特曼光斑图的MTF优于视网膜图像的MTF,说明眼内杂散光降低了视网膜的成像质量。根据眼内散射光偏振状态改变的特点,系统采用偏振光照明,抑制眼内散射光;利用补偿镜和位于眼前1 m位置处的视标,使照明光准确聚焦在视网膜血管层上,抑制视网膜多层组织反射杂光。通过对比实验,证明以上方法在一定程度上抑制了眼内杂散光对视网膜成像质量的影响。最后对4名志愿者进行了视网膜血管自适应成像实验,均获得了清晰的眼底视网膜血管图像。
Abstract
Using the liquid crystal spatial light modulator and Shack-Hartmann wave front sensor as the core components, an adaptive optics (AO) system for retinal imaging in vivo is constructed. Based on the modulation transfer function, quantitative analysis of the effects of the intraocular stray light on retinal imaging is carried out. The result demonstrates that the ocular stray light degrades the quality of the retinal images. According to the change characteristic of the polarization state of intraocular stray light. The fundus is illuminated by the polarized light. With the help of trial lens and sighting target with focal length of 1 m, the light source can be precisely focused on the capillary layer of the retina. Adopting the above mentioned methods, the effect of the ocular stray light is inhibited and the quality of retinal images is improved. Four volunteers participates in the experiments. The clear capillary images are obtained.
解洪升, 杨乐宝, 夏明亮, 李大禹, 宣丽. 抑制眼内杂散光提高视网膜成像质量方法研究[J]. 光学学报, 2014, 34(10): 1011004. Xie Hongsheng, Yang Lebao, Xia Mingliang, Li Dayu, Xuan Li. Inhibiting Intraocular Stray Light Method to Improve Quality of Retinal Image[J]. Acta Optica Sinica, 2014, 34(10): 1011004.