为了研究在人体血糖快速变化情况下, 皮肤组织液糖浓度与血液(指血、静脉血)中血糖变化的延迟关系,采用光学相干层析技术, 通过人体口服葡萄糖耐量测试和血糖钳夹实验, 测量了随血糖变化的皮肤光衰减系数, 并对人体血糖平衡延迟时间问题做了研究。为了避免由于延迟因素造成预测血糖值误差过大, 选择700μm ~800μm以下皮肤深度的真皮网状层作为分析计算区域。结果表明, 延迟时间一般随着皮肤区域深度的增加而缩短;在不同的皮肤深度区域, 血糖平衡延迟时间存在一定的差异性。此研究有助于提高光学无创血糖检测的准确性和可靠性。

To investigate the lag of glucose concentration between interstitial fluid of human skin and blood (peripheral blood and venous blood) during rapid change of blood glucose, optical coherence tomography (OCT) was used to measure attenuation coefficient of human skin with the change of blood glucose in oral glucose tolerance test and glucose clamp in vivo. To reduce error in prediction result, the correlation region used to calculate predicted glucose concentration should be selected below 700μm~800μm in dermis layer. The results show that lag time decreases with the increases of depth of human skin. It is demonstrated experimentally that the lag time changes at different depths in human skin. The study can improve the accuracy and reliability of measurement value in noninvasive blood glucose sensing.