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FTIR指纹图谱技术在禹余粮质量控制中的应用

Application of Fourier Transform Infrared Spectra (FTIR) Fingerprint in the Quality Control of Mineral Chinese Medicine Limonitum

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摘要

矿物药是中国传统药学中不可缺少的重要组成部分.禹余粮作为常用矿物药之一,在临床上有着广泛的使用和确切的疗效,长期用于治疗久泻,便血和崩漏带下.由于禹余粮原矿物成因复杂,通常由多种矿物组成,且组成比例不一,导致目前市场矿物药禹余粮品种来源较混乱,质量参差不齐,真假难以分辨.2010版《中国药典》所收载矿物药禹余粮的质量控制标准仅有简单的性状和铁盐的化学鉴别项目,不能很好的控制禹余粮的质量.通过FTIR方法建立矿物药禹余粮FTIR指纹图谱,并对禹余粮炮制前后及伪品FTIR图谱进行了比较分析.对不同产地和批次18份禹余粮样品进行分析,FTIR指纹图谱相似度评价以计算共有峰透光率的夹角余弦值获得.结果显示,禹余粮样品的FTIR指纹图谱相似度、相关系数均大于0.90;禹余粮生品、炮制品、伪品红外图谱存在较大差异.阐述了利用FTIR指纹图谱研究禹余粮的成分特征,能够快速、简便地区分真伪及炮制前后的禹余粮样品.禹余粮FTIR指纹图谱的建立为矿物药禹余粮质量评价提供了新方法,为《中国药典》禹余粮药材质量标准的完善提供了依据.

Abstract

In the present paper,the fingerprint of Limonitum (a mineral Chinese medicine) by FTIR was established,and the spectrograms among crude samples,processed one and the adulterant sample were compared.Eighteen batches of Limonitum samples from different production areas were analyzed and the angle cosine value of transmittance (%)of common peaks was calculated to get the similarity of the FTIR fingerprints.The result showed that the similarities and the coefficients of the samples were all more than 0.90.The processed samples revealed significant differences compared with the crude one.This study analyzed the composition characteristics of Limonitum in FTIR fingerprint,and it was simple and fast to distinguish the crude,processed and the counterfeit samples.The FTIR fingerprints provide a new method for evaluating the quality of Limonitum.

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中图分类号:O657.3

DOI:10.3964/j.issn.1000-0593(2015)04-0909-05

基金项目:Specificity Detection Methods and Standards Setting of Mineral Chinese Medicine,Revised China Pharmacopoeia 2015 Edition;National Natural Science Foundation of China (81303178);Natural Science Foundation of Jiangsu Province of China (BK20130957);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

收稿日期:2014-05-06

修改稿日期:2014-08-11

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作者单位    点击查看

刘圣金:南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023
杨欢:南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023
吴德康:南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023
徐春祥:江苏省食品药品检验所, 江苏 南京 210008
林瑞超:江苏省食品药品检验所, 江苏 南京 210008
田金改:中国食品药品检定研究院, 北京 100050
房方:南京中医药大学药学院,江苏省中药资源产业化过程协同创新中心,中药资源产业化与方剂创新药物国家地方联合工程研究中心, 江苏 南京 210023

联系人作者:LIUSheng-jin(13770653305@139.com)

备注:LIU Sheng-jin,(1978—),male,doctor,lecturer in Nanjing University of TCM

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引用该论文

LIU Sheng-jin,YANG Huan,WU De-kang,XU Chun-xiang,LIN Rui-chao,TIAN Jin-gai,FANG Fang. Application of Fourier Transform Infrared Spectra (FTIR) Fingerprint in the Quality Control of Mineral Chinese Medicine Limonitum[J]. Spectroscopy and Spectral Analysis, 2015, 35(4): 909-913

刘圣金,杨欢,吴德康,徐春祥,林瑞超,田金改,房方. FTIR指纹图谱技术在禹余粮质量控制中的应用[J]. 光谱学与光谱分析, 2015, 35(4): 909-913

被引情况

【1】王玉田,曹丽芳,杨 哲,严 冰,张丽娟. 基于FTIR, FT-Raman的脱毒繁育和硫磺熏制祁菊花的药用成分分析研究和光谱表征. 光谱学与光谱分析, 2016, 36(9): 2780-2783

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