为了提高宫颈癌的早期筛查效率以合理分配医疗资源, 研制了基于光电联合检测的宫颈癌早期筛查系统.系统顶端放置的光电极手持探头采用电脉冲、红光、绿光及近红外光交替分时刺激宫颈组织, 通过光电激励和测量,计算得到组织的光电学特征参数——电压衰减常数和相对反射率, 用组织分类算法实现了宫颈癌变的判别.将313例临床检验数据与组织病理检验金标准比对, 建立了光电激励下组织响应临床数据库.组织分类结果表明, 光电联合检测方法比单独光或电的检测在灵敏度、特异性和总符合率上有较大的提高, 与组织病理检验结果的对比表明本文所研发系统总符合率达85.1%, 对早期宫颈癌的筛查尤其是落后地区宫颈癌的筛查具有重要意义.

In order to improve the screening efficiency and in distribute medical resources rationally,a screening system of cervical pre-cancers based on the opto-electrical joint detection was developed.A hand-held detector with photoelectrodes on top stimulates the cervical tissue with electrical impulses,red light,green light and near-infrared light sequentially.The stimulation responses to opto-electircal stimulation were detected and calculated for the characteristic properties of tissue,which includes the voltage attenuation constant and relative reflectance.These two parameters were applied to classification algorithm to distinguish the cervical pre-cancers from the nornal tissue.313 clinical examples being covered,a clinical database of photoelectricity responses was established by comparying with the histopathological examinations.The results of tissue classification indicates the advantages of electro-optical combination in sensitivity,specificity and total coincidence rate over the separate electrical or optical detection.The total coincidence rate of this system with histopathological examinations achieves 85.1%.For the application,this system has the potential in enhancing the diagnosis rates of cervical pre-cancers with accuracy and portability,especially in underdeveloped areas.