激光生物学报, 2011, 20 (5): 695, 网络出版: 2015-10-08
高效液相法测定盐酸乐卡地平片含量
Determination of the Content of Lercanidipine Hydrochloride by HPLC
摘要
使用高效液相色谱法测定乐卡地平片含量, 流动相为乙腈-0.01 mol/L乙酸铵溶液-三乙胺(650∶350∶1)(pH 6.0)。结果显示盐酸乐卡地平在浓度为2.05～404.0 μg /mL范围内具有良好的线性关系, 盐酸乐卡地平片剂的平均标示量含量为100.3%, 符合要求。研究表明HPLC色谱法对乐卡地平片剂进行含量测定, 具有良好的线性、稳定性及精密度, 回收率高, 能够用于本品的含量测定。
Abstract
Determine the content of Lercanidipine Hydrochloride with high-performance liquid chromatography (HPLC). Use HPLC, mobile phase:acetonitrile-0.01 mol/L ammonium acetate solution - Triethylamine (650∶35∶1) (pH 6.0). Lercanidipine Hydrochloric has good linear relationship in the scope of the concentration of 2.05～404.0 μg /mL. The average contents of Lercanidipine Hydrochloric was 100.3%, which was in accordance with pharmacopoeial requirements. HPLC was used to determine the content of Lercanidipine Hydrochloric tablet, which has good linearity, stability, and precision,high efficiency. It can be used for the determination of Lercanidipine Hydrochloric.
李竹英, 刘胜姿, 陆艳艳, 邱细敏, 蒋诚, 李威. 高效液相法测定盐酸乐卡地平片含量[J]. 激光生物学报, 2011, 20(5): 695. LI Zhuying, LIU Shengzi, LU Yanyan, QIU Ximin, JIANG Cheng, LI Wei. Determination of the Content of Lercanidipine Hydrochloride by HPLC[J]. Acta Laser Biology Sinica, 2011, 20(5): 695.
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