激光生物学报, 2011, 20 (6): 843, 网络出版: 2015-10-08
基于光学相干层析成像技术的鼠皮肤II度烫伤及其修复过程监控
Monitoring the Second-degree Burn Skin of Rat and Its Renovated Process Based on Optical Coherence Tomography
摘要
建立小鼠皮肤的II度烫伤的模型, 分别于烫伤前、烫伤后1 min、8 h、1 d、3 d、5 d、7 d、9 d、11 d、13 d、15 d、17 d, 用光学相干层析成像技术(OCT)对烫伤的创面进行动态的监测, 同时对创面进行组织病理学的检测, 对结果进行分析。利用OCT 单次散射模型获得皮肤在烫伤前后光衰减系数的变化情况, 结果显示光衰减系数的值在烫伤后是呈先减小后增大的趋势, 待修复完全后又恢复到烫伤前相近的值。该结果与组织病理学的结果相吻合, 这表明OCT技术可以用于实时诊断烫伤的皮肤。
Abstract
The second-degree burn samples of rat skin were made and then an OCT was used to monitor the skin before scalded and 1minute, 8 hours, 1 day, 3 days, 5 days, 7 days, 9 days, 11 days, 13days, 15 days and 17 days after injury, respectively. The results were analyzed with the histological examination results. The attenuation coefficient during the process of scald was obtained by OCT single scattering model. And the result indicated that the attenuation coefficient decrease firstly, and then increase. After renovated completely, the skin value of attenuation coefficient is similar to that of un-scald one. The change of attenuation coefficient was consistent with the result of the corresponding histological results. The result demonstrated that OCT can be used to diagnose the burned skin and its renovated process in real time.
徐小晖, 吴淑莲, 李晖. 基于光学相干层析成像技术的鼠皮肤II度烫伤及其修复过程监控[J]. 激光生物学报, 2011, 20(6): 843. XU Xiaohui, WU Shulian, LI Hui. Monitoring the Second-degree Burn Skin of Rat and Its Renovated Process Based on Optical Coherence Tomography[J]. Acta Laser Biology Sinica, 2011, 20(6): 843.