光声治疗是一种利用纳米材料的光声效应选择性破坏癌细胞的方法。本研究采用叶酸作为肿瘤靶向分子, 以聚乙二醇包裹吲哚菁绿形成纳米粒子(ICG-PL-PEG-FA), 利用此纳米粒子在近红外区的光吸收特性, 开展光声治疗研究。实验结果表明, 这种叶酸标记的纳米探针对高表达叶酸的EMT6细胞具有高靶向选择性和靶向光杀伤性。这种基于包含吲哚菁绿纳米探针的光声治疗将有潜力发展为一种安全, 高效的癌症治疗技术。

Photoacoustic therapy is an approach using the photoacoustic effect of nanoparticle for targeting and selective destruction of cancer cells. Here, a novel functioned nanoprobe based on folic acid labeled indocyanine green-containing nanoparticle was developed to target and kill cancer cells under photoacoustic therapy. The results revealed that the nanoprobe had a high efficiency in cancer cell targeting and killing in folic acid positive EMT6 cells. The ICG-PL-PEG NPs based photoacoustic therapy would be a safe and highly efficient cancer treatment technique.