搭建了一台手持式扫频光学相干层析(SSOCT)系统对人体皮肤进行在体成像。对该系统的性能进行了详细的分析和讨论，并与实验室内现有的传统结构谱域光学相干层析(SDOCT)系统进行了对比，其中手持式SSOCT 系统的灵敏度为101 dB，SDOCT 系统的灵敏度为94 dB。通过一次样本模拟实验和两次人体不同位置皮肤成像的结果证明了手持式SSOCT 系统的信噪比和成像深度都优于SDOCT 系统。利用手持式SSOCT 系统对人体胳膊内侧成像，体现了手持式SSOCT 系统能够对任意位置皮肤成像的优越性。所有实验结果证明搭建的手持式SSOCT 系统除了具有使用方便的优点外，还能够提供高质量的人体皮肤微观结构图像。

A handheld swept source optical coherence tomography (SSOCT) system is described for imaging human skin in vivo. The performance of the system is analyzed in detail, and compared to the spectral domain optical coherence tomography (SDOCT) system in our laboratory. The results show that the sensitivity of the handheld SSOCT system and the traditional SDOCT system is 101 dB and 94 dB, respectively. A phantom experiment and two in vivo experiments on different human skin areas are carried out to demonstrate the better performance of the handheld SSOCT system in terms of signal to noise ratio (SNR) and the maximum imaging depth. The inner side of a human arm is imaged successfully with the handheld SSOCT system, which suggests that the handheld SSOCT system can image any position of human skin. All the results indicate that the handheld SSOCT system can not only be used to image skin anywhere conveniently, but also offer the structure images with high quality.