以3-巯基丙酸为稳定剂，采用水相合成法合成Mn掺杂的ZnS量子点，该量子点在室温条件下能够发射较强的磷光信号。十六烷基三甲基溴化铵（CTAB）作为一种阳离子表面活性剂能够与该量子点发生静电作用，最终与量子点聚合形成Mn掺杂的ZnS量子点/CTAB纳米复合材料，使量子点的室温磷光（RTP）强度明显增强。加入米托蒽醌（MXT）后，MXT能够与CTAB通过疏水作用和结构作用结合成为更加稳定的混合物，最终导致CTAB从量子点的表面脱离，进而使该量子点的室温磷光强度降低。结果表明该纳米复合材料能够大大提高量子点对MXT的检测性能，可由此建立高效、灵敏的检测MXT的室温磷光传感器。在最优条件下，该传感器对MXT的检出限为0.23 nmol/L，线性范围为0～200 nmol/L，相关系数R为0.99，且尿液和血清实际样品的检测回收率为98.6%～102.5%。该量子点磷光分析方法简便快速、灵敏度高、选择性好，能够用于体液中MXT含量的分析与检测。

With 3-mercaptopropionic acid as the stabilizer, Mn-doped ZnS quantum dots (QDs) are synthesized via the water phase method. These QDs emit strong phosphorescence at room temperature. These QDs aggregate with cetyl trimethylammonium bromide (CTAB) as a cation surfactant through electrostatic interaction to form Mn-doped ZnS QDs/CTAB nanohybrids, thereby largely enhancing the room-temperature phosphorescence (RTP) of QDs. The newly-added mitoxantrone (MXT) binds with CTAB through hydrophobic interaction and structure function to form more stable mixture, leading to separation of CTAB from the QD surfaces and reduction of the QD RTP intensity. The results indicate the nanohybrids can significantly improve the QD-based MXT detection ability. Thereby, a high-performance and high-sensitivity RTP sensor for MXT detection is established. Under the optimal conditions, this sensor has a MXT detection limit of 0.23 nmol/L and linear range from 0 to 200 nmol/L (correlation coefficient R=0.99). The results with real urine and serum samples are with recovery rate of 98.6%～102.5%. The phosphorescence detection method is simple, rapid, sensitive and selective, and can be used well for analysis and detection of MXT in body fluid.