Chinese Optics Letters, 2016, 14 (7): 071702, Published Online: Aug. 3, 2018  

Early-photon guided reconstruction method for time-domain fluorescence lifetime tomography Download: 766次

Author Affiliations
1 Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China
2 Center for Biomedical Imaging Research, Tsinghua University, Beijing 100084, China
Abstract
A reconstruction method guided by early-photon fluorescence yield tomography is proposed for time-domain fluorescence lifetime tomography (FLT) in this study. The method employs the early-arriving photons to reconstruct a fluorescence yield map, which is utilized as a priori information to reconstruct the FLT via all the photons along the temporal-point spread functions. Phantom experiments demonstrate that, compared with the method using all the photons for reconstruction of fluorescence yield and lifetime maps, the proposed method can achieve higher spatial resolution and reduced crosstalk between different targets without sacrificing the quantification accuracy of lifetime and contrast between heterogeneous targets.

Lin Zhang, Chuangjian Cai, Yanlu Lv, Jianwen Luo. Early-photon guided reconstruction method for time-domain fluorescence lifetime tomography[J]. Chinese Optics Letters, 2016, 14(7): 071702.

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