Two kinds of Nb-doped silica fibers, an NbCl5-doped fiber and an Nb2O5-doped fiber, are fabricated and characterized in this Letter. First, the refractive index profiles of both fibers are obtained, and then their Raman spectra are measured with 785 nm exciting light. The Nb-doped fibers’ Raman spectra are compared with a conventional GeO2-doped single-mode silica fiber that is prepared with the same method and under the same conditions. As a result, the Raman gain coefficients of the Nb-doped silica fiber core are obtained. The experimental results show that Nb2O5 doping can enhance the Raman scattering intensity of the optical fibers.